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Effect of corrections for blood glucose and body size on [F-18]FDG PET standardised uptake values in lung cancer

Research output: Contribution to journalArticle

W. A. Hallett, P. K. Marsden, B. F. Cronin, M. J. O'Doherty

Original languageEnglish
Pages (from-to)919 - 922
Number of pages4
JournalEuropean Journal of Nuclear Medicine
Volume28
Issue number7
DOIs
Published2001

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Abstract

Standardised uptake values (SUVs) are commonly used as a semi-quantitative index of 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) tracer uptake in positron emission tomography (PET). Studies have shown that SUVs may depend on body size and blood glucose concentration and corrections for these effects have been proposed in the literature. This retrospective study investigated the effect of the proposed corrections on SUVs from a group of 154 patients with lung cancer who had scans on a dedicated PET scanner. A total of 252 SUVs were requested as an aid to staging during consideration for surgical resection. SUVs were calculated normalised to body weight (SUVW), lean body mass (SUVLBM) and body surface area (SUVBSA). The following correlations were examined: SUV with height, weight and body surface area for the different body size normalisations; SUVW and SUVW x blood glucose (SUVBG) with blood glucose; SUVW with scan time post injection; and SUVW with apparent lesion diameter. Significant correlations were only observed between: SUVLBM and height (P=0.007); SUVW and scan time (P=0.007); SUVW and lesion diameter (P=0.0005); and SUVBG and blood glucose (P

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