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Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom: A national cohort study

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Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom : A national cohort study. / Phillips, Benedict; Ibrahim, Maria; Greenhall, George et al.

In: American Journal of Transplantation, Vol. 21, No. 10, 10.2021, p. 3346-3355.

Research output: Contribution to journalArticlepeer-review

Harvard

Phillips, B, Ibrahim, M, Greenhall, G, Mumford, L, Dorling, A & Callaghan, C 2021, 'Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom: A national cohort study', American Journal of Transplantation, vol. 21, no. 10, pp. 3346-3355. https://doi.org/10.1111/ajt.16574

APA

Phillips, B., Ibrahim, M., Greenhall, G., Mumford, L., Dorling, A., & Callaghan, C. (2021). Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom: A national cohort study. American Journal of Transplantation, 21(10), 3346-3355. https://doi.org/10.1111/ajt.16574

Vancouver

Phillips B, Ibrahim M, Greenhall G, Mumford L, Dorling A, Callaghan C. Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom: A national cohort study. American Journal of Transplantation. 2021 Oct;21(10):3346-3355. https://doi.org/10.1111/ajt.16574

Author

Phillips, Benedict ; Ibrahim, Maria ; Greenhall, George et al. / Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom : A national cohort study. In: American Journal of Transplantation. 2021 ; Vol. 21, No. 10. pp. 3346-3355.

Bibtex Download

@article{f13db46e503142e188d81fc3acda2fe4,
title = "Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom: A national cohort study",
abstract = "Kidneys from donation after circulatory death (DCD) donors are utilized variably worldwide, in part due to high rates of delayed graft function (DGF) and putative associations with adverse longer-term outcomes. We aimed to determine whether the presence of DGF and its duration were associated with poor longer-term outcomes after kidney transplantation from DCD donors. Using the UK transplant registry, we identified 4714 kidney-only transplants from controlled DCD donors to adult recipients between 2006 and 2016; 2832 recipients (60·1%) had immediate graft function and 1882 (39·9%) had DGF. Of the 1847 recipients with DGF duration recorded, 926 (50·1%) had DGF < 7 days, 576 (31·2%) had DGF 7–14 days, and 345 (18·7%) had DGF >14 days. After risk adjustment, the presence of DGF was not associated with inferior long-term graft or patient survivals. However, DGF duration of >14 days was associated with an increased risk of death-censored graft failure (hazard ratio 1·7, p = ·001) and recipient death (hazard ratio 1·8, p < ·001) compared to grafts with immediate function. This study suggests that shorter periods of DGF have no adverse influence on graft or patient survival after DCD donor kidney transplantation and that DGF >14 days is a novel early biomarker for significantly worse longer-term outcomes.",
author = "Benedict Phillips and Maria Ibrahim and George Greenhall and Lisa Mumford and Anthony Dorling and Christopher Callaghan",
note = "Funding Information: The authors of this manuscript have conflicts of interest to disclose as described by the . Benedict L. Phillips{\textquoteright} salary was funded by a grant from Kidney Research UK. The salaries of Maria Ibrahim and George H. B. Greenhall were funded by fellowships from National Health Service Blood and Transplant. American Journal of Transplantation Publisher Copyright: {\textcopyright} 2021 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = oct,
doi = "10.1111/ajt.16574",
language = "English",
volume = "21",
pages = "3346--3355",
journal = "American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the United Kingdom

T2 - A national cohort study

AU - Phillips, Benedict

AU - Ibrahim, Maria

AU - Greenhall, George

AU - Mumford, Lisa

AU - Dorling, Anthony

AU - Callaghan, Christopher

N1 - Funding Information: The authors of this manuscript have conflicts of interest to disclose as described by the . Benedict L. Phillips’ salary was funded by a grant from Kidney Research UK. The salaries of Maria Ibrahim and George H. B. Greenhall were funded by fellowships from National Health Service Blood and Transplant. American Journal of Transplantation Publisher Copyright: © 2021 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/10

Y1 - 2021/10

N2 - Kidneys from donation after circulatory death (DCD) donors are utilized variably worldwide, in part due to high rates of delayed graft function (DGF) and putative associations with adverse longer-term outcomes. We aimed to determine whether the presence of DGF and its duration were associated with poor longer-term outcomes after kidney transplantation from DCD donors. Using the UK transplant registry, we identified 4714 kidney-only transplants from controlled DCD donors to adult recipients between 2006 and 2016; 2832 recipients (60·1%) had immediate graft function and 1882 (39·9%) had DGF. Of the 1847 recipients with DGF duration recorded, 926 (50·1%) had DGF < 7 days, 576 (31·2%) had DGF 7–14 days, and 345 (18·7%) had DGF >14 days. After risk adjustment, the presence of DGF was not associated with inferior long-term graft or patient survivals. However, DGF duration of >14 days was associated with an increased risk of death-censored graft failure (hazard ratio 1·7, p = ·001) and recipient death (hazard ratio 1·8, p < ·001) compared to grafts with immediate function. This study suggests that shorter periods of DGF have no adverse influence on graft or patient survival after DCD donor kidney transplantation and that DGF >14 days is a novel early biomarker for significantly worse longer-term outcomes.

AB - Kidneys from donation after circulatory death (DCD) donors are utilized variably worldwide, in part due to high rates of delayed graft function (DGF) and putative associations with adverse longer-term outcomes. We aimed to determine whether the presence of DGF and its duration were associated with poor longer-term outcomes after kidney transplantation from DCD donors. Using the UK transplant registry, we identified 4714 kidney-only transplants from controlled DCD donors to adult recipients between 2006 and 2016; 2832 recipients (60·1%) had immediate graft function and 1882 (39·9%) had DGF. Of the 1847 recipients with DGF duration recorded, 926 (50·1%) had DGF < 7 days, 576 (31·2%) had DGF 7–14 days, and 345 (18·7%) had DGF >14 days. After risk adjustment, the presence of DGF was not associated with inferior long-term graft or patient survivals. However, DGF duration of >14 days was associated with an increased risk of death-censored graft failure (hazard ratio 1·7, p = ·001) and recipient death (hazard ratio 1·8, p < ·001) compared to grafts with immediate function. This study suggests that shorter periods of DGF have no adverse influence on graft or patient survival after DCD donor kidney transplantation and that DGF >14 days is a novel early biomarker for significantly worse longer-term outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85104852579&partnerID=8YFLogxK

U2 - 10.1111/ajt.16574

DO - 10.1111/ajt.16574

M3 - Article

VL - 21

SP - 3346

EP - 3355

JO - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

SN - 1600-6135

IS - 10

ER -

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