King's College London

Research portal

Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials

Research output: Contribution to journalArticle

Standard

Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes : meta-analysis of individual participant data from randomised trials. / International Weight Management in Pregnancy (i-WIP) Collaborative Group; Rogozinska, E; Marlin, N; Betran, A P; Astrup, A; Barakat, R; Boagaerts , A; Cecatti, J G; Devlieger, R; Dodd, J; El-Beltagy, N; Facchinetti , F; Geiker, N R W; K, Guelfi; Hakkstad , L A H; Harrison, C; Hauner, H; Jensen, D M; Kinnunen, T I; Khoury, J; Luoto, R; McAuliffe, F; Motahari, N; Morkved, S; Owens, J; Perales, M; Petrella, E; Phela , E; Poston, Lucilla; Rauh, K; Renault , K M; Sagedal, L R; Salvesen , K A; Shen, G X; Shub, A; Scudeller, T; Surita, F G; Stafne, S N; Teede, H; Tonstad, S; van Poppel, M N M; Vinter, C A; Vistad , I; Yeo, S A; Dodds, J; Kerry, S; Jackson, L; Barton, P; Molyneaux, E; Martin, A A; Rayanagoudar, G.

In: British Medical Journal, Vol. 358, j3119, 19.07.2017.

Research output: Contribution to journalArticle

Harvard

International Weight Management in Pregnancy (i-WIP) Collaborative Group, Rogozinska, E, Marlin, N, Betran, AP, Astrup, A, Barakat, R, Boagaerts , A, Cecatti, JG, Devlieger, R, Dodd, J, El-Beltagy, N, Facchinetti , F, Geiker, NRW, K, G, Hakkstad , LAH, Harrison, C, Hauner, H, Jensen, DM, Kinnunen, TI, Khoury, J, Luoto, R, McAuliffe, F, Motahari, N, Morkved, S, Owens, J, Perales, M, Petrella, E, Phela , E, Poston, L, Rauh, K, Renault , KM, Sagedal, LR, Salvesen , KA, Shen, GX, Shub, A, Scudeller, T, Surita, FG, Stafne, SN, Teede, H, Tonstad, S, van Poppel, MNM, Vinter, CA, Vistad , I, Yeo, SA, Dodds, J, Kerry, S, Jackson, L, Barton, P, Molyneaux, E, Martin, AA & Rayanagoudar, G 2017, 'Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials', British Medical Journal, vol. 358, j3119. https://doi.org/10.1136/bmj.j3119

APA

International Weight Management in Pregnancy (i-WIP) Collaborative Group, Rogozinska, E., Marlin, N., Betran, A. P., Astrup, A., Barakat, R., ... Rayanagoudar, G. (2017). Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials. British Medical Journal, 358, [j3119]. https://doi.org/10.1136/bmj.j3119

Vancouver

International Weight Management in Pregnancy (i-WIP) Collaborative Group, Rogozinska E, Marlin N, Betran AP, Astrup A, Barakat R et al. Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials. British Medical Journal. 2017 Jul 19;358. j3119. https://doi.org/10.1136/bmj.j3119

Author

International Weight Management in Pregnancy (i-WIP) Collaborative Group ; Rogozinska, E ; Marlin, N ; Betran, A P ; Astrup, A ; Barakat, R ; Boagaerts , A ; Cecatti, J G ; Devlieger, R ; Dodd, J ; El-Beltagy, N ; Facchinetti , F ; Geiker, N R W ; K, Guelfi ; Hakkstad , L A H ; Harrison, C ; Hauner, H ; Jensen, D M ; Kinnunen, T I ; Khoury, J ; Luoto, R ; McAuliffe, F ; Motahari, N ; Morkved, S ; Owens, J ; Perales, M ; Petrella, E ; Phela , E ; Poston, Lucilla ; Rauh, K ; Renault , K M ; Sagedal, L R ; Salvesen , K A ; Shen, G X ; Shub, A ; Scudeller, T ; Surita, F G ; Stafne, S N ; Teede, H ; Tonstad, S ; van Poppel, M N M ; Vinter, C A ; Vistad , I ; Yeo, S A ; Dodds, J ; Kerry, S ; Jackson, L ; Barton, P ; Molyneaux, E ; Martin, A A ; Rayanagoudar, G. / Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes : meta-analysis of individual participant data from randomised trials. In: British Medical Journal. 2017 ; Vol. 358.

Bibtex Download

@article{41c72137fd0e4b49b651b59ce2378285,
title = "Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials",
abstract = "Objective To synthesise the evidence on the overall and differential effects of interventions based on diet and physical activity during pregnancy, primarily on gestational weight gain and maternal and offspring composite outcomes, according to women’s body mass index, age, parity, ethnicity, and pre-existing medical condition; and secondarily on individual complications.Design Systematic review and meta-analysis of individual participant data (IPD).Data sources Major electronic databases from inception to February 2017 without language restrictions.Eligibility criteria for selecting studies Randomised trials on diet and physical activity based interventions in pregnancy.Data synthesis Statistical models accounted for clustering of participants within trials and heterogeneity across trials leading to summary mean differences or odds ratios with 95{\%} confidence intervals for the effects overall, and in subgroups (interactions).Results IPD were obtained from 36 randomised trials (12 526 women). Less weight gain occurred in the intervention group than control group (mean difference −0.70 kg, 95{\%} confidence interval −0.92 to −0.48 kg, I2=14.1{\%}; 33 studies, 9320 women). Although summary effect estimates favoured the intervention, the reductions in maternal (odds ratio 0.90, 95{\%} confidence interval 0.79 to 1.03, I2=26.7{\%}; 24 studies, 8852 women) and offspring (0.94, 0.83 to 1.08, I2=0{\%}; 18 studies, 7981 women) composite outcomes were not statistically significant. No evidence was found of differential intervention effects across subgroups, for either gestational weight gain or composite outcomes. There was strong evidence that interventions reduced the odds of caesarean section (0.91, 0.83 to 0.99, I2=0{\%}; 32 studies, 11 410 women), but not for other individual complications in IPD meta-analysis. When IPD were supplemented with study level data from studies that did not provide IPD, the overall effect was similar, with stronger evidence of benefit for gestational diabetes (0.76, 0.65 to 0.89, I2=36.8{\%}; 59 studies, 16 885 women).Conclusion Diet and physical activity based interventions during pregnancy reduce gestational weight gain and lower the odds of caesarean section. There is no evidence that effects differ across subgroups of women.",
keywords = "Diet, Exercise Therapy, Female, Humans, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Randomized Controlled Trials as Topic, Weight Gain, Journal Article, Meta-Analysis, Review",
author = "{International Weight Management in Pregnancy (i-WIP) Collaborative Group} and E Rogozinska and N Marlin and Betran, {A P} and A Astrup and R Barakat and A Boagaerts and Cecatti, {J G} and R Devlieger and J Dodd and N El-Beltagy and F Facchinetti and Geiker, {N R W} and Guelfi K and Hakkstad, {L A H} and C Harrison and H Hauner and Jensen, {D M} and Kinnunen, {T I} and J Khoury and R Luoto and F McAuliffe and N Motahari and S Morkved and J Owens and M Perales and E Petrella and E Phela and Lucilla Poston and K Rauh and Renault, {K M} and Sagedal, {L R} and Salvesen, {K A} and Shen, {G X} and A Shub and T Scudeller and Surita, {F G} and Stafne, {S N} and H Teede and S Tonstad and {van Poppel}, {M N M} and Vinter, {C A} and I Vistad and Yeo, {S A} and J Dodds and S Kerry and L Jackson and P Barton and E Molyneaux and Martin, {A A} and G Rayanagoudar",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",
year = "2017",
month = "7",
day = "19",
doi = "10.1136/bmj.j3119",
language = "English",
volume = "358",
journal = "BMJ, British Medical Journal (Clinical Research Ed.)",
issn = "0959-535X",
publisher = "BMJ Publishing Group Ltd",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes

T2 - meta-analysis of individual participant data from randomised trials

AU - International Weight Management in Pregnancy (i-WIP) Collaborative Group

AU - Rogozinska, E

AU - Marlin, N

AU - Betran, A P

AU - Astrup, A

AU - Barakat, R

AU - Boagaerts , A

AU - Cecatti, J G

AU - Devlieger, R

AU - Dodd, J

AU - El-Beltagy, N

AU - Facchinetti , F

AU - Geiker, N R W

AU - K, Guelfi

AU - Hakkstad , L A H

AU - Harrison, C

AU - Hauner, H

AU - Jensen, D M

AU - Kinnunen, T I

AU - Khoury, J

AU - Luoto, R

AU - McAuliffe, F

AU - Motahari, N

AU - Morkved, S

AU - Owens, J

AU - Perales, M

AU - Petrella, E

AU - Phela , E

AU - Poston, Lucilla

AU - Rauh, K

AU - Renault , K M

AU - Sagedal, L R

AU - Salvesen , K A

AU - Shen, G X

AU - Shub, A

AU - Scudeller, T

AU - Surita, F G

AU - Stafne, S N

AU - Teede, H

AU - Tonstad, S

AU - van Poppel, M N M

AU - Vinter, C A

AU - Vistad , I

AU - Yeo, S A

AU - Dodds, J

AU - Kerry, S

AU - Jackson, L

AU - Barton, P

AU - Molyneaux, E

AU - Martin, A A

AU - Rayanagoudar, G

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2017/7/19

Y1 - 2017/7/19

N2 - Objective To synthesise the evidence on the overall and differential effects of interventions based on diet and physical activity during pregnancy, primarily on gestational weight gain and maternal and offspring composite outcomes, according to women’s body mass index, age, parity, ethnicity, and pre-existing medical condition; and secondarily on individual complications.Design Systematic review and meta-analysis of individual participant data (IPD).Data sources Major electronic databases from inception to February 2017 without language restrictions.Eligibility criteria for selecting studies Randomised trials on diet and physical activity based interventions in pregnancy.Data synthesis Statistical models accounted for clustering of participants within trials and heterogeneity across trials leading to summary mean differences or odds ratios with 95% confidence intervals for the effects overall, and in subgroups (interactions).Results IPD were obtained from 36 randomised trials (12 526 women). Less weight gain occurred in the intervention group than control group (mean difference −0.70 kg, 95% confidence interval −0.92 to −0.48 kg, I2=14.1%; 33 studies, 9320 women). Although summary effect estimates favoured the intervention, the reductions in maternal (odds ratio 0.90, 95% confidence interval 0.79 to 1.03, I2=26.7%; 24 studies, 8852 women) and offspring (0.94, 0.83 to 1.08, I2=0%; 18 studies, 7981 women) composite outcomes were not statistically significant. No evidence was found of differential intervention effects across subgroups, for either gestational weight gain or composite outcomes. There was strong evidence that interventions reduced the odds of caesarean section (0.91, 0.83 to 0.99, I2=0%; 32 studies, 11 410 women), but not for other individual complications in IPD meta-analysis. When IPD were supplemented with study level data from studies that did not provide IPD, the overall effect was similar, with stronger evidence of benefit for gestational diabetes (0.76, 0.65 to 0.89, I2=36.8%; 59 studies, 16 885 women).Conclusion Diet and physical activity based interventions during pregnancy reduce gestational weight gain and lower the odds of caesarean section. There is no evidence that effects differ across subgroups of women.

AB - Objective To synthesise the evidence on the overall and differential effects of interventions based on diet and physical activity during pregnancy, primarily on gestational weight gain and maternal and offspring composite outcomes, according to women’s body mass index, age, parity, ethnicity, and pre-existing medical condition; and secondarily on individual complications.Design Systematic review and meta-analysis of individual participant data (IPD).Data sources Major electronic databases from inception to February 2017 without language restrictions.Eligibility criteria for selecting studies Randomised trials on diet and physical activity based interventions in pregnancy.Data synthesis Statistical models accounted for clustering of participants within trials and heterogeneity across trials leading to summary mean differences or odds ratios with 95% confidence intervals for the effects overall, and in subgroups (interactions).Results IPD were obtained from 36 randomised trials (12 526 women). Less weight gain occurred in the intervention group than control group (mean difference −0.70 kg, 95% confidence interval −0.92 to −0.48 kg, I2=14.1%; 33 studies, 9320 women). Although summary effect estimates favoured the intervention, the reductions in maternal (odds ratio 0.90, 95% confidence interval 0.79 to 1.03, I2=26.7%; 24 studies, 8852 women) and offspring (0.94, 0.83 to 1.08, I2=0%; 18 studies, 7981 women) composite outcomes were not statistically significant. No evidence was found of differential intervention effects across subgroups, for either gestational weight gain or composite outcomes. There was strong evidence that interventions reduced the odds of caesarean section (0.91, 0.83 to 0.99, I2=0%; 32 studies, 11 410 women), but not for other individual complications in IPD meta-analysis. When IPD were supplemented with study level data from studies that did not provide IPD, the overall effect was similar, with stronger evidence of benefit for gestational diabetes (0.76, 0.65 to 0.89, I2=36.8%; 59 studies, 16 885 women).Conclusion Diet and physical activity based interventions during pregnancy reduce gestational weight gain and lower the odds of caesarean section. There is no evidence that effects differ across subgroups of women.

KW - Diet

KW - Exercise Therapy

KW - Female

KW - Humans

KW - Obesity

KW - Pregnancy

KW - Pregnancy Complications

KW - Pregnancy Outcome

KW - Randomized Controlled Trials as Topic

KW - Weight Gain

KW - Journal Article

KW - Meta-Analysis

KW - Review

U2 - 10.1136/bmj.j3119

DO - 10.1136/bmj.j3119

M3 - Article

C2 - 28724518

VL - 358

JO - BMJ, British Medical Journal (Clinical Research Ed.)

JF - BMJ, British Medical Journal (Clinical Research Ed.)

SN - 0959-535X

M1 - j3119

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454