Effect of enprostil, a synthetic prostaglandin E2 on 24 hour intragastric acidity, nocturnal acid and pepsin secretion

M. Deakin, J. Ramage, A. Paul, S. P. Gray, J. Billings, J. G. Williams

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

We have studied the effect of a prostaglandin E2 analogue (enprostil), on intragastric acidity, gastric acid and pepsin outputs during a 24 hour period in nine patients with duodenal ulcer in remission. Enprostil 35 μg bd dose inhibited 24 hour intragastric acidity by 38% and a 70 μg nocturnal dose by 33%. Decrease in nocturnal pepsin secretion was both volume and concentration related.

Original languageEnglish
Pages (from-to)1054-1057
Number of pages4
JournalGut
Volume27
Issue number9
DOIs
Publication statusPublished - 1986

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