Effect of ethnicity on the clinical presentation and outcome of autoimmune hepatitis

Rodrigo Liberal, Diego Vergani

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Autoimmune hepatitis (AIH) is a progressive inflammatory disorder affecting children and adults of both sexes. Although AIH is known to occur in all geographical areas, racial differences have not been studied systematically. The paper by Wong et al. reports a retrospective study analyzing AIH epidemiology among ethnically different populations referred to a tertiary-care hospital. A total of 183 patients were included and divided according to their ethnicity into Hispanic, Asian and Caucasian groups. Age at diagnosis and sex distribution was similar in all three groups. Compared with Caucasians, Asian patients had a higher international normalized ratio, whereas, in addition to higher international normalized ratio, Hispanics also showed lower levels of albumin and platelets, as well as higher prevalence of biopsy-proven cirrhosis at presentation. Despite this, Kaplan Meier analysis showed that Hispanics had the best survival outcomes, followed by Caucasians. Asians had the poorest survival outcome.

    Original languageEnglish
    Pages (from-to)267-269
    Number of pages3
    JournalExpert review of gastroenterology & hepatology
    Volume6
    Issue number3
    DOIs
    Publication statusPublished - Jun 2012

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