Effect of maltitol-containing chewing gum use on the composition of dental plaque microbiota in subjects with active dental caries

TY - JOUR

T1 - Effect of maltitol-containing chewing gum use on the composition of dental plaque microbiota in subjects with active dental caries

AU - Prosdocimi, Erica M

AU - Kistler, James O

AU - Moazzez, Rebecca

AU - Thabuis, Clementine

AU - Perreau, Caroline

AU - Wade, William G

PY - 2017

Y1 - 2017

N2 - Background: Sugar alcohols such as xylitol are incorporated in a number of oral hygiene products for their anti-cariogenic properties while chewing gum is known to be beneficial to oral hygiene.Objective: The aim of this study was to determine the composition of the dental plaque microbiota in patients with active caries before and after using a chewing gum supplemented with maltitol.Design: Forty subjects with active caries were randomly allocated to chew maltitol gum or gum base for two weeks. A healthy control group used gum base for two weeks. Plaque samples were collected before and after treatment and the microbiota analysed by pyrosequencing of 16S rRNA genes.Results: A total of 773,547 sequences were obtained from 117 samples. There was no difference in structure of the bacterial communities between groups (AMOVA). There was a significant difference in community membership between groups, (AMOVA, p=0.009). There was a significant difference between the control group after treatment and the maltitol patient group after treatment (p<0.001). A. naeslundiiHOT-176 and Actinomyces HOT-169 were significantly reduced following use of maltitol chewing gum in patients.Conclusions: This study has shown that chewing gum containing maltitol had minor effects on the composition of the plaque microbiome.

AB - Background: Sugar alcohols such as xylitol are incorporated in a number of oral hygiene products for their anti-cariogenic properties while chewing gum is known to be beneficial to oral hygiene.Objective: The aim of this study was to determine the composition of the dental plaque microbiota in patients with active caries before and after using a chewing gum supplemented with maltitol.Design: Forty subjects with active caries were randomly allocated to chew maltitol gum or gum base for two weeks. A healthy control group used gum base for two weeks. Plaque samples were collected before and after treatment and the microbiota analysed by pyrosequencing of 16S rRNA genes.Results: A total of 773,547 sequences were obtained from 117 samples. There was no difference in structure of the bacterial communities between groups (AMOVA). There was a significant difference in community membership between groups, (AMOVA, p=0.009). There was a significant difference between the control group after treatment and the maltitol patient group after treatment (p<0.001). A. naeslundiiHOT-176 and Actinomyces HOT-169 were significantly reduced following use of maltitol chewing gum in patients.Conclusions: This study has shown that chewing gum containing maltitol had minor effects on the composition of the plaque microbiome.

U2 - 10.1080/20002297.2017.1374152

DO - 10.1080/20002297.2017.1374152

M3 - Article

C2 - 29081913

SN - 2000-2297

VL - 9

SP - 1374152

JO - Molecular Oral Microbiology

JF - Molecular Oral Microbiology

IS - 1

ER -