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Effect of maltitol-containing chewing gum use on the composition of dental plaque microbiota in subjects with active dental caries

Research output: Contribution to journalArticle

Erica M Prosdocimi, James O Kistler, Rebecca Moazzez, Clementine Thabuis, Caroline Perreau, William G Wade

Original languageEnglish
Pages (from-to)1374152
JournalMolecular Oral Microbiology
Volume9
Issue number1
DOIs
Publication statusPublished - 2017

King's Authors

Abstract

Background: Sugar alcohols such as xylitol are incorporated in a number of oral hygiene products for their anti-cariogenic properties while chewing gum is known to be beneficial to oral hygiene.

Objective: The aim of this study was to determine the composition of the dental plaque microbiota in patients with active caries before and after using a chewing gum supplemented with maltitol.

Design: Forty subjects with active caries were randomly allocated to chew maltitol gum or gum base for two weeks. A healthy control group used gum base for two weeks. Plaque samples were collected before and after treatment and the microbiota analysed by pyrosequencing of 16S rRNA genes.

Results: A total of 773,547 sequences were obtained from 117 samples. There was no difference in structure of the bacterial communities between groups (AMOVA). There was a significant difference in community membership between groups, (AMOVA, p=0.009). There was a significant difference between the control group after treatment and the maltitol patient group after treatment (p<0.001). A. naeslundiiHOT-176 and Actinomyces HOT-169 were significantly reduced following use of maltitol chewing gum in patients.

Conclusions: This study has shown that chewing gum containing maltitol had minor effects on the composition of the plaque microbiome.

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