Abstract
A 30 second burst of microwave irradiation at an energy level insufficient to cause DNA denaturation or damage drives the covalent reaction between pyrrolobenzodiazepine (PBD) antitumour agents and double-stranded or hairpin oligonucleotides to completion, a process that normally takes between 3–24 hours and thus offering the opportunity for higher-throughput screening of covalent-binding DNA-interactive agents.
| Original language | English |
|---|---|
| Pages (from-to) | 2875 - 2877 |
| Number of pages | 3 |
| Journal | Chemical communications (Cambridge, England) |
| Volume | 2009 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2009 |