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Effect of support matrix on ratio of product to by-product formation in L-phenylacetyl carbinol synthesis

Research output: Contribution to journalArticle

Penka Nikolova, Owen P. Ward

Original languageEnglish
Article numberN/A
Pages (from-to)7-10
Number of pages4
Issue number1
Publication statusPublished - 1 Jan 1994

King's Authors


Production of L-phenylacetyl carbinol (PAC) and benzyl alcohol by biotransformation from pyruvate and benzaldehyde substrates was investigated using yeast cells in different polymeric matrices. Highest concentration of PAC was produced by cells immobilised in the hydrophilic matrix, ENT-4000. Highest concentration of the by-product, benzyl alcohol, was produced in the hydrophobic matrix, ENTP-2000. Ratio of PAC to benzyl alcohol ranged from 1∶0.08 for cells entrapped in a poly(propyleneglycol)-containing polymer, PU-3, to 1∶1.8 for cells entrapped in ENTP-2000 polymer.

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