Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

K. Lavrenkov; S. Singh; J. A. Christian; M. Partridge; E. Nioutsikou; G. Cook; J. L. Bedford; M. Brada

doi:10.1016/j.radonc.2008.10.005

Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

K. Lavrenkov, S. Singh, J. A. Christian, M. Partridge, E. Nioutsikou, G. Cook, J. L. Bedford, M. Brada

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Abstract

IMIRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V(20) and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung. (C) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 349-352

Original language	English
Pages (from-to)	349-352
Number of pages	4
Journal	Radiotherapy and Oncology
Volume	91
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2008.10.005
Publication status	Published - Jun 2009

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Lavrenkov, K., Singh, S., Christian, J. A., Partridge, M., Nioutsikou, E., Cook, G., Bedford, J. L., & Brada, M. (2009). Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study. Radiotherapy and Oncology, 91(3), 349-352. https://doi.org/10.1016/j.radonc.2008.10.005

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abstract = "IMIRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V(20) and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung. (C) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 349-352",

author = "K. Lavrenkov and S. Singh and Christian, {J. A.} and M. Partridge and E. Nioutsikou and G. Cook and Bedford, {J. L.} and M. Brada",

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Lavrenkov, K, Singh, S, Christian, JA, Partridge, M, Nioutsikou, E, Cook, G, Bedford, JL & Brada, M 2009, 'Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study', Radiotherapy and Oncology, vol. 91, no. 3, pp. 349-352. https://doi.org/10.1016/j.radonc.2008.10.005

TY - JOUR

T1 - Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

AU - Lavrenkov, K.

AU - Singh, S.

AU - Christian, J. A.

AU - Partridge, M.

AU - Nioutsikou, E.

AU - Cook, G.

AU - Bedford, J. L.

AU - Brada, M.

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N2 - IMIRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V(20) and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung. (C) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 349-352

AB - IMIRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V(20) and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung. (C) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 349-352

U2 - 10.1016/j.radonc.2008.10.005

DO - 10.1016/j.radonc.2008.10.005

M3 - Article

SN - 0167-8140

VL - 91

SP - 349

EP - 352

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 3

ER -

Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

Abstract

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