TY - JOUR
T1 - Effectiveness of Nutritional Supplementation on Muscle Mass in Treatment of Sarcopenia in Old Age
T2 - A Systematic Review
AU - Malafarina, Vincenzo
AU - Uriz-Otano, Francisco
AU - Iniesta, Raquel
AU - Gil-Guerrero, Lucía
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Background: Much interest has been focused on nutritional treatment of sarcopenia, loss of muscle mass and performance associated to aging; however, its benefits are unclear. Objective: To analyze the relevance of nutritional treatment of sarcopenia and assess the effects of supplementation on muscle mass and function within the aged population. Methods: We searched Medline and the Cochrane Library for controlled trials published between 1991 and 2012. We have assessed the quality, type of intervention, the cohort used, the way muscle mass was measured, and the outcomes of the various studies. Results: We have included 17 studies, with a total of 1287 patients, aged between 65 and 85 on average. An improvement in muscle mass was proven, whether measured with bioelectrical impedance analysis or dual energy x-ray absorptiometry, and an improvement in strength was also proven. Conclusion: Nutritional supplementation is effective in the treatment of sarcopenia in old age, and its positive effects increase when associated with physical exercise. The main limitation of this treatment is lack of long-term adherence. A healthy diet associated with a physically active lifestyle and possibly with aerobic exercise are the basis of healthy aging, which is the aim of all doctors treating aged people must seek.
AB - Background: Much interest has been focused on nutritional treatment of sarcopenia, loss of muscle mass and performance associated to aging; however, its benefits are unclear. Objective: To analyze the relevance of nutritional treatment of sarcopenia and assess the effects of supplementation on muscle mass and function within the aged population. Methods: We searched Medline and the Cochrane Library for controlled trials published between 1991 and 2012. We have assessed the quality, type of intervention, the cohort used, the way muscle mass was measured, and the outcomes of the various studies. Results: We have included 17 studies, with a total of 1287 patients, aged between 65 and 85 on average. An improvement in muscle mass was proven, whether measured with bioelectrical impedance analysis or dual energy x-ray absorptiometry, and an improvement in strength was also proven. Conclusion: Nutritional supplementation is effective in the treatment of sarcopenia in old age, and its positive effects increase when associated with physical exercise. The main limitation of this treatment is lack of long-term adherence. A healthy diet associated with a physically active lifestyle and possibly with aerobic exercise are the basis of healthy aging, which is the aim of all doctors treating aged people must seek.
KW - Fat-free-mass
KW - Muscle mass
KW - Oral supplement
KW - Sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=84871682492&partnerID=8YFLogxK
U2 - 10.1016/j.jamda.2012.08.001
DO - 10.1016/j.jamda.2012.08.001
M3 - Review article
C2 - 22980996
AN - SCOPUS:84871682492
SN - 1525-8610
VL - 14
SP - 10
EP - 17
JO - Journal Of The American Medical Directors Association
JF - Journal Of The American Medical Directors Association
IS - 1
ER -