Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses

L. M. Buffart; M. A.C. Schreurs; H. J.G. Abrahams; J. Kalter; N. K. Aaronson; P. B. Jacobsen; R. U. Newton; K. S. Courneya; J. Armes; C. Arving; A. M. Braamse; Y. Brandberg; J. Dekker; R. J. Ferguson; M. F. Gielissen; B. Glimelius; M. M. Goedendorp; K. D. Graves; S. P. Heiney; R. Horne; M. S. Hunter; B. Johansson; L. L. Northouse; H. S. Oldenburg; J. B. Prins; J. Savard; M. van Beurden; S. W. van den Berg; J. Brug; H. Knoop; I. M. Verdonck-de Leeuw

doi:10.1016/j.cpr.2020.101882

Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses

L. M. Buffart^*, M. A.C. Schreurs, H. J.G. Abrahams, J. Kalter, N. K. Aaronson, P. B. Jacobsen, R. U. Newton, K. S. Courneya, J. Armes, C. Arving, A. M. Braamse, Y. Brandberg, J. Dekker, R. J. Ferguson, M. F. Gielissen, B. Glimelius, M. M. Goedendorp, K. D. Graves, S. P. Heiney, R. HorneM. S. Hunter, B. Johansson, L. L. Northouse, H. S. Oldenburg, J. B. Prins, J. Savard, M. van Beurden, S. W. van den Berg, J. Brug, H. Knoop, I. M. Verdonck-de Leeuw

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Purpose: This study evaluated the effects of coping skills training (CST) on symptoms of depression and anxiety in cancer patients, and investigated moderators of the effects. Methods: Overall effects and intervention-related moderators were studied in meta-analyses of pooled aggregate data from 38 randomized controlled trials (RCTs). Patient-related moderators were examined using linear mixed-effect models with interaction tests on pooled individual patient data (n = 1953) from 15 of the RCTs. Results: CST had a statistically significant but small effect on depression (g = −0.31,95% confidence interval (CI) = −0.40;-0.22) and anxiety (g = −0.32,95%CI = -0.41;-0.24) symptoms. Effects on depression symptoms were significantly larger for interventions delivered face-to-face (p =.003), led by a psychologist (p =.02) and targeted to patients with psychological distress (p =.002). Significantly larger reductions in anxiety symptoms were found in younger patients (p_interaction < 0.025), with the largest reductions in patients <50 years (β = −0.31,95%CI = -0.44;-0.18) and no significant effects in patients ≥70 years. Effects of CST on depression (β = −0.16,95%CI = -0.25;-0.07) and anxiety (β = −0.24,95%CI = -0.33;-0.14) symptoms were significant in patients who received chemotherapy but not in patients who did not (p_interaction < 0.05). Conclusions: CST significantly reduced symptoms of depression and anxiety in cancer patients, and particularly when delivered face-to-face, provided by a psychologist, targeted to patients with psychological distress, and given to patients who were younger and received chemotherapy.

Original language	English
Article number	101882
Journal	Clinical Psychology Review
Volume	80
DOIs	https://doi.org/10.1016/j.cpr.2020.101882
Publication status	Published - Aug 2020

Keywords

(individual patient data) meta-analysis
Anxiety
Coping skills training
Depression
Neoplasm
Psychosocial care

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cpr.2020.101882

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Buffart, L. M., Schreurs, M. A. C., Abrahams, H. J. G., Kalter, J., Aaronson, N. K., Jacobsen, P. B., Newton, R. U., Courneya, K. S., Armes, J., Arving, C., Braamse, A. M., Brandberg, Y., Dekker, J., Ferguson, R. J., Gielissen, M. F., Glimelius, B., Goedendorp, M. M., Graves, K. D., Heiney, S. P., ... Verdonck-de Leeuw, I. M. (2020). Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses. Clinical Psychology Review, 80, [101882]. https://doi.org/10.1016/j.cpr.2020.101882

@article{09456b0c7912482597465d7cd65f2e7d,

title = "Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses",

abstract = "Purpose: This study evaluated the effects of coping skills training (CST) on symptoms of depression and anxiety in cancer patients, and investigated moderators of the effects. Methods: Overall effects and intervention-related moderators were studied in meta-analyses of pooled aggregate data from 38 randomized controlled trials (RCTs). Patient-related moderators were examined using linear mixed-effect models with interaction tests on pooled individual patient data (n = 1953) from 15 of the RCTs. Results: CST had a statistically significant but small effect on depression (g = −0.31,95% confidence interval (CI) = −0.40;-0.22) and anxiety (g = −0.32,95%CI = -0.41;-0.24) symptoms. Effects on depression symptoms were significantly larger for interventions delivered face-to-face (p =.003), led by a psychologist (p =.02) and targeted to patients with psychological distress (p =.002). Significantly larger reductions in anxiety symptoms were found in younger patients (pinteraction < 0.025), with the largest reductions in patients <50 years (β = −0.31,95%CI = -0.44;-0.18) and no significant effects in patients ≥70 years. Effects of CST on depression (β = −0.16,95%CI = -0.25;-0.07) and anxiety (β = −0.24,95%CI = -0.33;-0.14) symptoms were significant in patients who received chemotherapy but not in patients who did not (pinteraction < 0.05). Conclusions: CST significantly reduced symptoms of depression and anxiety in cancer patients, and particularly when delivered face-to-face, provided by a psychologist, targeted to patients with psychological distress, and given to patients who were younger and received chemotherapy.",

keywords = "(individual patient data) meta-analysis, Anxiety, Coping skills training, Depression, Neoplasm, Psychosocial care",

author = "Buffart, {L. M.} and Schreurs, {M. A.C.} and Abrahams, {H. J.G.} and J. Kalter and Aaronson, {N. K.} and Jacobsen, {P. B.} and Newton, {R. U.} and Courneya, {K. S.} and J. Armes and C. Arving and Braamse, {A. M.} and Y. Brandberg and J. Dekker and Ferguson, {R. J.} and Gielissen, {M. F.} and B. Glimelius and Goedendorp, {M. M.} and Graves, {K. D.} and Heiney, {S. P.} and R. Horne and Hunter, {M. S.} and B. Johansson and Northouse, {L. L.} and Oldenburg, {H. S.} and Prins, {J. B.} and J. Savard and {van Beurden}, M. and {van den Berg}, {S. W.} and J. Brug and H. Knoop and {Verdonck-de Leeuw}, {I. M.}",

year = "2020",

month = aug,

doi = "10.1016/j.cpr.2020.101882",

language = "English",

volume = "80",

journal = "Clinical Psychology Review",

issn = "0272-7358",

publisher = "Elsevier Inc.",

}

Buffart, LM, Schreurs, MAC, Abrahams, HJG, Kalter, J, Aaronson, NK, Jacobsen, PB, Newton, RU, Courneya, KS, Armes, J, Arving, C, Braamse, AM, Brandberg, Y, Dekker, J, Ferguson, RJ, Gielissen, MF, Glimelius, B, Goedendorp, MM, Graves, KD, Heiney, SP, Horne, R, Hunter, MS, Johansson, B, Northouse, LL, Oldenburg, HS, Prins, JB, Savard, J, van Beurden, M, van den Berg, SW, Brug, J, Knoop, H & Verdonck-de Leeuw, IM 2020, 'Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses', Clinical Psychology Review, vol. 80, 101882. https://doi.org/10.1016/j.cpr.2020.101882

TY - JOUR

T1 - Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer

T2 - Aggregate data and individual patient data meta-analyses

AU - Buffart, L. M.

AU - Schreurs, M. A.C.

AU - Abrahams, H. J.G.

AU - Kalter, J.

AU - Aaronson, N. K.

AU - Jacobsen, P. B.

AU - Newton, R. U.

AU - Courneya, K. S.

AU - Armes, J.

AU - Arving, C.

AU - Braamse, A. M.

AU - Brandberg, Y.

AU - Dekker, J.

AU - Ferguson, R. J.

AU - Gielissen, M. F.

AU - Glimelius, B.

AU - Goedendorp, M. M.

AU - Graves, K. D.

AU - Heiney, S. P.

AU - Horne, R.

AU - Hunter, M. S.

AU - Johansson, B.

AU - Northouse, L. L.

AU - Oldenburg, H. S.

AU - Prins, J. B.

AU - Savard, J.

AU - van Beurden, M.

AU - van den Berg, S. W.

AU - Brug, J.

AU - Knoop, H.

AU - Verdonck-de Leeuw, I. M.

PY - 2020/8

Y1 - 2020/8

N2 - Purpose: This study evaluated the effects of coping skills training (CST) on symptoms of depression and anxiety in cancer patients, and investigated moderators of the effects. Methods: Overall effects and intervention-related moderators were studied in meta-analyses of pooled aggregate data from 38 randomized controlled trials (RCTs). Patient-related moderators were examined using linear mixed-effect models with interaction tests on pooled individual patient data (n = 1953) from 15 of the RCTs. Results: CST had a statistically significant but small effect on depression (g = −0.31,95% confidence interval (CI) = −0.40;-0.22) and anxiety (g = −0.32,95%CI = -0.41;-0.24) symptoms. Effects on depression symptoms were significantly larger for interventions delivered face-to-face (p =.003), led by a psychologist (p =.02) and targeted to patients with psychological distress (p =.002). Significantly larger reductions in anxiety symptoms were found in younger patients (pinteraction < 0.025), with the largest reductions in patients <50 years (β = −0.31,95%CI = -0.44;-0.18) and no significant effects in patients ≥70 years. Effects of CST on depression (β = −0.16,95%CI = -0.25;-0.07) and anxiety (β = −0.24,95%CI = -0.33;-0.14) symptoms were significant in patients who received chemotherapy but not in patients who did not (pinteraction < 0.05). Conclusions: CST significantly reduced symptoms of depression and anxiety in cancer patients, and particularly when delivered face-to-face, provided by a psychologist, targeted to patients with psychological distress, and given to patients who were younger and received chemotherapy.

AB - Purpose: This study evaluated the effects of coping skills training (CST) on symptoms of depression and anxiety in cancer patients, and investigated moderators of the effects. Methods: Overall effects and intervention-related moderators were studied in meta-analyses of pooled aggregate data from 38 randomized controlled trials (RCTs). Patient-related moderators were examined using linear mixed-effect models with interaction tests on pooled individual patient data (n = 1953) from 15 of the RCTs. Results: CST had a statistically significant but small effect on depression (g = −0.31,95% confidence interval (CI) = −0.40;-0.22) and anxiety (g = −0.32,95%CI = -0.41;-0.24) symptoms. Effects on depression symptoms were significantly larger for interventions delivered face-to-face (p =.003), led by a psychologist (p =.02) and targeted to patients with psychological distress (p =.002). Significantly larger reductions in anxiety symptoms were found in younger patients (pinteraction < 0.025), with the largest reductions in patients <50 years (β = −0.31,95%CI = -0.44;-0.18) and no significant effects in patients ≥70 years. Effects of CST on depression (β = −0.16,95%CI = -0.25;-0.07) and anxiety (β = −0.24,95%CI = -0.33;-0.14) symptoms were significant in patients who received chemotherapy but not in patients who did not (pinteraction < 0.05). Conclusions: CST significantly reduced symptoms of depression and anxiety in cancer patients, and particularly when delivered face-to-face, provided by a psychologist, targeted to patients with psychological distress, and given to patients who were younger and received chemotherapy.

KW - (individual patient data) meta-analysis

KW - Anxiety

KW - Coping skills training

KW - Depression

KW - Neoplasm

KW - Psychosocial care

UR - http://www.scopus.com/inward/record.url?scp=85087341188&partnerID=8YFLogxK

U2 - 10.1016/j.cpr.2020.101882

DO - 10.1016/j.cpr.2020.101882

M3 - Review article

AN - SCOPUS:85087341188

SN - 0272-7358

VL - 80

JO - Clinical Psychology Review

JF - Clinical Psychology Review

M1 - 101882

ER -

Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses

Abstract

Keywords

UN SDGs

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