TY - JOUR
T1 - Effects of a personalized nutrition program on cardiometabolic health
T2 - a randomized controlled trial
AU - Bermingham, Kate
AU - Linenberg, Inbar
AU - Polidori, Lorenzo
AU - Asnicar, Francesco
AU - Arre, Alberto
AU - Wolf, Jonathan
AU - Badri, Fatema
AU - Bernard, Hannah
AU - Capdevila, Joan
AU - Bulsiewicz, William J.
AU - Gardner, Christopher D.
AU - Ordovas, José M
AU - Davies, Richard
AU - Hadjigeorgiou, George
AU - Hall, Wendy
AU - Delahanty, Linda M.
AU - Valdes, Ana
AU - Segata, Nicola
AU - Spector, Tim
AU - Berry, Sarah
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/5/8
Y1 - 2024/5/8
N2 - Large variability exists in people’s responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health using a randomized clinical trial. The PDP used food characteristics, individual postprandial glucose and triglyceride (TG) responses to foods, microbiomes and health history, to produce personalized food scores in an 18-week app-based program. The control group received standard care dietary advice (US Department of Agriculture Guidelines for Americans, 2020–2025) using online resources, check-ins, video lessons and a leaflet. Primary outcomes were serum low-density lipoprotein cholesterol and TG concentrations at baseline and at 18 weeks. Participants (n = 347), aged 41–70 years and generally representative of the average US population, were randomized to the PDP (n = 177) or control (n = 170). Intention-to-treat analysis (n = 347) between groups showed significant reduction in TGs (mean difference = −0.13 mmol l
−1; log-transformed 95% confidence interval = −0.07 to −0.01, P = 0.016). Changes in low-density lipoprotein cholesterol were not significant. There were improvements in secondary outcomes, including body weight, waist circumference, HbA1c, diet quality and microbiome (beta-diversity) (P < 0.05), particularly in highly adherent PDP participants. However, blood pressure, insulin, glucose, C-peptide, apolipoprotein A1 and B, and postprandial TGs did not differ between groups. No serious intervention-related adverse events were reported. Following a personalized diet led to some improvements in cardiometabolic health compared to standard dietary advice. ClinicalTrials.gov registration: NCT05273268.
AB - Large variability exists in people’s responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health using a randomized clinical trial. The PDP used food characteristics, individual postprandial glucose and triglyceride (TG) responses to foods, microbiomes and health history, to produce personalized food scores in an 18-week app-based program. The control group received standard care dietary advice (US Department of Agriculture Guidelines for Americans, 2020–2025) using online resources, check-ins, video lessons and a leaflet. Primary outcomes were serum low-density lipoprotein cholesterol and TG concentrations at baseline and at 18 weeks. Participants (n = 347), aged 41–70 years and generally representative of the average US population, were randomized to the PDP (n = 177) or control (n = 170). Intention-to-treat analysis (n = 347) between groups showed significant reduction in TGs (mean difference = −0.13 mmol l
−1; log-transformed 95% confidence interval = −0.07 to −0.01, P = 0.016). Changes in low-density lipoprotein cholesterol were not significant. There were improvements in secondary outcomes, including body weight, waist circumference, HbA1c, diet quality and microbiome (beta-diversity) (P < 0.05), particularly in highly adherent PDP participants. However, blood pressure, insulin, glucose, C-peptide, apolipoprotein A1 and B, and postprandial TGs did not differ between groups. No serious intervention-related adverse events were reported. Following a personalized diet led to some improvements in cardiometabolic health compared to standard dietary advice. ClinicalTrials.gov registration: NCT05273268.
UR - http://www.scopus.com/inward/record.url?scp=85192396041&partnerID=8YFLogxK
U2 - 10.1038/s41591-024-02951-6
DO - 10.1038/s41591-024-02951-6
M3 - Article
SN - 1546-170X
VL - 30
SP - 1888
EP - 1897
JO - Nature Medicine
JF - Nature Medicine
IS - 7
ER -