Effects of acute antipsychotic treatment on brain activation in first episode psychosis: An fMRI study

TY - JOUR

T1 - Effects of acute antipsychotic treatment on brain activation in first episode psychosis

T2 - An fMRI study

AU - Fusar-Poli, Paolo

AU - Broome, M. R.

AU - Matthiasson, P.

AU - Williams, S. C. R.

AU - Brammer, M.

AU - McGuire, P. K.

PY - 2007/5

Y1 - 2007/5

N2 - This study aimed to assess the neurophysiotogical effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.

AB - This study aimed to assess the neurophysiotogical effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.

U2 - 10.1016/j.euroneuro.2007.01.003

DO - 10.1016/j.euroneuro.2007.01.003

M3 - Article

SN - 0924-977X

VL - 17

SP - 492

EP - 500

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 6-7

ER -