Effects of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers

V Kumari; P A Cotter; O F Mulligan; S A Checkley; N S Gray; D R Hemsley; J C Thornton; P J Corr; B K Toone; J A Gray

Effects of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers

V Kumari, P A Cotter, O F Mulligan, S A Checkley, N S Gray, D R Hemsley, J C Thornton, P J Corr, B K Toone, J A Gray

Psychology

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Latent inhibition (LI) refers to a retardation of learning about the consequences of a stimulus when that stimulus has been passively presented a number of times without reinforcement. Acute positive-symptom schizophrenics, normal volunteers who score high on questionnaire measures of schizotypy and non-patients or animals treated with dopamine agonists show reduced LI. Neuroleptic drugs, such as haloperidol, administered at low doses, potentiate LI and effectively reverse disruption of LI induced by dopamine agonists in animals. However, a high dose of haloperidol, administered on its own, has been found to reduce LI. We examined the effects on LI of acute oral administration of an indirect dopamine-agonist, d-amphetamine (5 mg), and a nonselective dopamine receptor antagonist, haloperidol (5 mg), in normal male volunteers, using an associative learning task. Replicating previous reports, we found that d-amphetamine reduced LI; haloperidol also reduced LI, but only in subjects who scored low on the Psychoticism. scale of the Eysenck Personality Questionnaire. In a subsequent study no effect was found of 2 mg oral haloperidol administration on LI. The effect of 5 mg haloperidol on LI is interpreted as similar to that observed with a high dose of haloperidol in rats.

Original language	English
Pages (from-to)	398 - 405
Number of pages	8
Journal	Journal of Psychopharmacology
Volume	13
Issue number	4
Publication status	Published - 1999

Cite this

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title = "Effects of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers",

abstract = "Latent inhibition (LI) refers to a retardation of learning about the consequences of a stimulus when that stimulus has been passively presented a number of times without reinforcement. Acute positive-symptom schizophrenics, normal volunteers who score high on questionnaire measures of schizotypy and non-patients or animals treated with dopamine agonists show reduced LI. Neuroleptic drugs, such as haloperidol, administered at low doses, potentiate LI and effectively reverse disruption of LI induced by dopamine agonists in animals. However, a high dose of haloperidol, administered on its own, has been found to reduce LI. We examined the effects on LI of acute oral administration of an indirect dopamine-agonist, d-amphetamine (5 mg), and a nonselective dopamine receptor antagonist, haloperidol (5 mg), in normal male volunteers, using an associative learning task. Replicating previous reports, we found that d-amphetamine reduced LI; haloperidol also reduced LI, but only in subjects who scored low on the Psychoticism. scale of the Eysenck Personality Questionnaire. In a subsequent study no effect was found of 2 mg oral haloperidol administration on LI. The effect of 5 mg haloperidol on LI is interpreted as similar to that observed with a high dose of haloperidol in rats.",

author = "V Kumari and Cotter, {P A} and Mulligan, {O F} and Checkley, {S A} and Gray, {N S} and Hemsley, {D R} and Thornton, {J C} and Corr, {P J} and Toone, {B K} and Gray, {J A}",

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language = "English",

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pages = "398 -- 405",

journal = "Journal of Psychopharmacology",

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T1 - Effects of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers

AU - Kumari, V

AU - Cotter, P A

AU - Mulligan, O F

AU - Checkley, S A

AU - Gray, N S

AU - Hemsley, D R

AU - Thornton, J C

AU - Corr, P J

AU - Toone, B K

AU - Gray, J A

PY - 1999

Y1 - 1999

N2 - Latent inhibition (LI) refers to a retardation of learning about the consequences of a stimulus when that stimulus has been passively presented a number of times without reinforcement. Acute positive-symptom schizophrenics, normal volunteers who score high on questionnaire measures of schizotypy and non-patients or animals treated with dopamine agonists show reduced LI. Neuroleptic drugs, such as haloperidol, administered at low doses, potentiate LI and effectively reverse disruption of LI induced by dopamine agonists in animals. However, a high dose of haloperidol, administered on its own, has been found to reduce LI. We examined the effects on LI of acute oral administration of an indirect dopamine-agonist, d-amphetamine (5 mg), and a nonselective dopamine receptor antagonist, haloperidol (5 mg), in normal male volunteers, using an associative learning task. Replicating previous reports, we found that d-amphetamine reduced LI; haloperidol also reduced LI, but only in subjects who scored low on the Psychoticism. scale of the Eysenck Personality Questionnaire. In a subsequent study no effect was found of 2 mg oral haloperidol administration on LI. The effect of 5 mg haloperidol on LI is interpreted as similar to that observed with a high dose of haloperidol in rats.

AB - Latent inhibition (LI) refers to a retardation of learning about the consequences of a stimulus when that stimulus has been passively presented a number of times without reinforcement. Acute positive-symptom schizophrenics, normal volunteers who score high on questionnaire measures of schizotypy and non-patients or animals treated with dopamine agonists show reduced LI. Neuroleptic drugs, such as haloperidol, administered at low doses, potentiate LI and effectively reverse disruption of LI induced by dopamine agonists in animals. However, a high dose of haloperidol, administered on its own, has been found to reduce LI. We examined the effects on LI of acute oral administration of an indirect dopamine-agonist, d-amphetamine (5 mg), and a nonselective dopamine receptor antagonist, haloperidol (5 mg), in normal male volunteers, using an associative learning task. Replicating previous reports, we found that d-amphetamine reduced LI; haloperidol also reduced LI, but only in subjects who scored low on the Psychoticism. scale of the Eysenck Personality Questionnaire. In a subsequent study no effect was found of 2 mg oral haloperidol administration on LI. The effect of 5 mg haloperidol on LI is interpreted as similar to that observed with a high dose of haloperidol in rats.

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M3 - Article

SN - 1461-7285

VL - 13

SP - 398

EP - 405

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

IS - 4

ER -

Effects of d-amphetamine and haloperidol on latent inhibition in healthy male volunteers

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