King's College London

Research portal

Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta-analysis

Research output: Contribution to journalReview article

Standard

Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence : A network meta-analysis. / Hsieh, Meng Tsang; Tseng, Ping Tao; Wu, Yi Cheng; Tu, Yu Kang; Wu, Hung Chi; Hsu, Chih Wei; Lei, Wei Te; Stubbs, Brendon; Carvalho, Andre F.; Liang, Chih Sung; Yeh, Ta Chuan; Chen, Tien Yu; Chu, Che Sheng; Li, Juo Chi; Yu, Chia Ling; Chen, Yen Wen; Li, Dian Jeng.

In: OBESITY REVIEWS, Vol. 20, No. 6, 01.06.2019, p. 895-905.

Research output: Contribution to journalReview article

Harvard

Hsieh, MT, Tseng, PT, Wu, YC, Tu, YK, Wu, HC, Hsu, CW, Lei, WT, Stubbs, B, Carvalho, AF, Liang, CS, Yeh, TC, Chen, TY, Chu, CS, Li, JC, Yu, CL, Chen, YW & Li, DJ 2019, 'Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta-analysis', OBESITY REVIEWS, vol. 20, no. 6, pp. 895-905. https://doi.org/10.1111/obr.12835

APA

Hsieh, M. T., Tseng, P. T., Wu, Y. C., Tu, Y. K., Wu, H. C., Hsu, C. W., Lei, W. T., Stubbs, B., Carvalho, A. F., Liang, C. S., Yeh, T. C., Chen, T. Y., Chu, C. S., Li, J. C., Yu, C. L., Chen, Y. W., & Li, D. J. (2019). Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta-analysis. OBESITY REVIEWS, 20(6), 895-905. https://doi.org/10.1111/obr.12835

Vancouver

Hsieh MT, Tseng PT, Wu YC, Tu YK, Wu HC, Hsu CW et al. Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta-analysis. OBESITY REVIEWS. 2019 Jun 1;20(6):895-905. https://doi.org/10.1111/obr.12835

Author

Hsieh, Meng Tsang ; Tseng, Ping Tao ; Wu, Yi Cheng ; Tu, Yu Kang ; Wu, Hung Chi ; Hsu, Chih Wei ; Lei, Wei Te ; Stubbs, Brendon ; Carvalho, Andre F. ; Liang, Chih Sung ; Yeh, Ta Chuan ; Chen, Tien Yu ; Chu, Che Sheng ; Li, Juo Chi ; Yu, Chia Ling ; Chen, Yen Wen ; Li, Dian Jeng. / Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence : A network meta-analysis. In: OBESITY REVIEWS. 2019 ; Vol. 20, No. 6. pp. 895-905.

Bibtex Download

@article{75c86f9a6808486a8a49ee1f94b34cbb,
title = "Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta-analysis",
abstract = "Smoking cessation is a public health priority to reduce smoking-related morbidity and mortality. However, weight gain is a known primary reason for not trying to quit smoking. The aim of the current study was to investigate differences in weight gain associated with different pharmacological smoking cessation interventions. Randomized controlled trials (RCTs) that reported weight gain related to pharmacologic treatments for smoking cessation were analysed using network meta-analysis with a random effects model. Thirty-one RCTs with 5650 participants were included. Ten drugs and 22 regimens were identified. Nicotine patches plus fluoxetine, topiramate with/without nicotine patches, nicotine patches plus methylphenidate, nicotine spray/gum/lozenges, high-dose nicotine patches (42 mg/21 mg), naltrexone with/without nicotine patches, or bupropion with/without nicotine patches were associated with less weight gain than the placebo/control arm. Nicotine patches plus fluoxetine were associated with the least weight gain of all smoking cessation treatments. In addition, the nicotine patch plus topiramate and nicotine inhaler was associated with the best success rate and the least dropout rate, respectively. Overall, the nicotine patch 14 mg plus fluoxetine 40 mg, nicotine patch 14 mg plus fluoxetine 20 mg, and topiramate 200 mg would be the three best pharmacologic treatments based upon both weight gain effect and success rate.",
keywords = "adverse effect, body weight, network meta-analysis, nicotine dependence, smoke cessation, weight gain",
author = "Hsieh, {Meng Tsang} and Tseng, {Ping Tao} and Wu, {Yi Cheng} and Tu, {Yu Kang} and Wu, {Hung Chi} and Hsu, {Chih Wei} and Lei, {Wei Te} and Brendon Stubbs and Carvalho, {Andre F.} and Liang, {Chih Sung} and Yeh, {Ta Chuan} and Chen, {Tien Yu} and Chu, {Che Sheng} and Li, {Juo Chi} and Yu, {Chia Ling} and Chen, {Yen Wen} and Li, {Dian Jeng}",
year = "2019",
month = jun,
day = "1",
doi = "10.1111/obr.12835",
language = "English",
volume = "20",
pages = "895--905",
journal = "OBESITY REVIEWS",
issn = "1467-7881",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence

T2 - A network meta-analysis

AU - Hsieh, Meng Tsang

AU - Tseng, Ping Tao

AU - Wu, Yi Cheng

AU - Tu, Yu Kang

AU - Wu, Hung Chi

AU - Hsu, Chih Wei

AU - Lei, Wei Te

AU - Stubbs, Brendon

AU - Carvalho, Andre F.

AU - Liang, Chih Sung

AU - Yeh, Ta Chuan

AU - Chen, Tien Yu

AU - Chu, Che Sheng

AU - Li, Juo Chi

AU - Yu, Chia Ling

AU - Chen, Yen Wen

AU - Li, Dian Jeng

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Smoking cessation is a public health priority to reduce smoking-related morbidity and mortality. However, weight gain is a known primary reason for not trying to quit smoking. The aim of the current study was to investigate differences in weight gain associated with different pharmacological smoking cessation interventions. Randomized controlled trials (RCTs) that reported weight gain related to pharmacologic treatments for smoking cessation were analysed using network meta-analysis with a random effects model. Thirty-one RCTs with 5650 participants were included. Ten drugs and 22 regimens were identified. Nicotine patches plus fluoxetine, topiramate with/without nicotine patches, nicotine patches plus methylphenidate, nicotine spray/gum/lozenges, high-dose nicotine patches (42 mg/21 mg), naltrexone with/without nicotine patches, or bupropion with/without nicotine patches were associated with less weight gain than the placebo/control arm. Nicotine patches plus fluoxetine were associated with the least weight gain of all smoking cessation treatments. In addition, the nicotine patch plus topiramate and nicotine inhaler was associated with the best success rate and the least dropout rate, respectively. Overall, the nicotine patch 14 mg plus fluoxetine 40 mg, nicotine patch 14 mg plus fluoxetine 20 mg, and topiramate 200 mg would be the three best pharmacologic treatments based upon both weight gain effect and success rate.

AB - Smoking cessation is a public health priority to reduce smoking-related morbidity and mortality. However, weight gain is a known primary reason for not trying to quit smoking. The aim of the current study was to investigate differences in weight gain associated with different pharmacological smoking cessation interventions. Randomized controlled trials (RCTs) that reported weight gain related to pharmacologic treatments for smoking cessation were analysed using network meta-analysis with a random effects model. Thirty-one RCTs with 5650 participants were included. Ten drugs and 22 regimens were identified. Nicotine patches plus fluoxetine, topiramate with/without nicotine patches, nicotine patches plus methylphenidate, nicotine spray/gum/lozenges, high-dose nicotine patches (42 mg/21 mg), naltrexone with/without nicotine patches, or bupropion with/without nicotine patches were associated with less weight gain than the placebo/control arm. Nicotine patches plus fluoxetine were associated with the least weight gain of all smoking cessation treatments. In addition, the nicotine patch plus topiramate and nicotine inhaler was associated with the best success rate and the least dropout rate, respectively. Overall, the nicotine patch 14 mg plus fluoxetine 40 mg, nicotine patch 14 mg plus fluoxetine 20 mg, and topiramate 200 mg would be the three best pharmacologic treatments based upon both weight gain effect and success rate.

KW - adverse effect

KW - body weight

KW - network meta-analysis

KW - nicotine dependence

KW - smoke cessation

KW - weight gain

UR - http://www.scopus.com/inward/record.url?scp=85062328788&partnerID=8YFLogxK

U2 - 10.1111/obr.12835

DO - 10.1111/obr.12835

M3 - Review article

AN - SCOPUS:85062328788

VL - 20

SP - 895

EP - 905

JO - OBESITY REVIEWS

JF - OBESITY REVIEWS

SN - 1467-7881

IS - 6

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454