Effects of DTNBP1 genotype on brain development in children

Stefania Tognin, Essi Viding, Eamon J McCrory, Lauren Taylor, Michael C O'Donovan, Philip McGuire, Andrea Mechelli

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Schizophrenia is a neurodevelopmental disorder, and risk genes are thought to act through disruption of brain development. Several genetic studies have identified dystrobrevin-binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain development is poorly understood. The present investigation examined for the first time the effects of DTNBP1 on brain structure in children. Our hypothesis was that a genetic variation in DTNBP1 (i.e., the single nucleotide polymorphism rs2619538) would be associated with differences in both gray and white matter brain regions previously implicated in schizophrenia.
Original languageEnglish
Pages (from-to)1287-94
Number of pages8
JournalJournal of Child Psychology and Psychiatry
Issue number12
Early online date3 Jun 2011
Publication statusPublished - Dec 2011


Dive into the research topics of 'Effects of DTNBP1 genotype on brain development in children'. Together they form a unique fingerprint.

Cite this