TY - JOUR
T1 - Effects of DTNBP1 genotype on brain development in children
AU - Tognin, Stefania
AU - Viding, Essi
AU - McCrory, Eamon J
AU - Taylor, Lauren
AU - O'Donovan, Michael C
AU - McGuire, Philip
AU - Mechelli, Andrea
N1 - © 2011 The Authors. Journal of Child Psychology and Psychiatry © 2011 Association for Child and Adolescent Mental Health.
PY - 2011/12
Y1 - 2011/12
N2 - Schizophrenia is a neurodevelopmental disorder, and risk genes are thought to act through disruption of brain development. Several genetic studies have identified dystrobrevin-binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain development is poorly understood. The present investigation examined for the first time the effects of DTNBP1 on brain structure in children. Our hypothesis was that a genetic variation in DTNBP1 (i.e., the single nucleotide polymorphism rs2619538) would be associated with differences in both gray and white matter brain regions previously implicated in schizophrenia.
AB - Schizophrenia is a neurodevelopmental disorder, and risk genes are thought to act through disruption of brain development. Several genetic studies have identified dystrobrevin-binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain development is poorly understood. The present investigation examined for the first time the effects of DTNBP1 on brain structure in children. Our hypothesis was that a genetic variation in DTNBP1 (i.e., the single nucleotide polymorphism rs2619538) would be associated with differences in both gray and white matter brain regions previously implicated in schizophrenia.
U2 - 10.1111/j.1469-7610.2011.02427.x
DO - 10.1111/j.1469-7610.2011.02427.x
M3 - Article
C2 - 21639861
SN - 1469-7610
VL - 52
SP - 1287
EP - 1294
JO - Journal of Child Psychology and Psychiatry
JF - Journal of Child Psychology and Psychiatry
IS - 12
ER -