Effects of estrogen replacement therapy on human brain aging: An in vivo H-1 MRS study

TY - JOUR

T1 - Effects of estrogen replacement therapy on human brain aging: An in vivo H-1 MRS study

AU - Robertson, D M W

AU - van Amelsvoort, T

AU - Daly, E

AU - Simmons, A

AU - Whitehead, M

AU - Morris, R G

AU - Murphy, K C

AU - Murphy, D G M

PY - 2001

Y1 - 2001

N2 - Estrogen replacement therapy (ERT) may preserve cognitive function in postmenopausal women, but the mechanism is unknown. Thus, the authors studied aging of parietal lobe and hippocampus using proton MR spectroscopy. ERT naive postmenopausal women had a significant increase in choline-containing compounds (Cho) compared to long-term ERT users and young women. Cho reflects increased neuronal/glial membrane turnover. Thus, ERT's "neuroprotective" effect may include modulating the effects of age on neural integrity in brain regions involved in cognitive function.

AB - Estrogen replacement therapy (ERT) may preserve cognitive function in postmenopausal women, but the mechanism is unknown. Thus, the authors studied aging of parietal lobe and hippocampus using proton MR spectroscopy. ERT naive postmenopausal women had a significant increase in choline-containing compounds (Cho) compared to long-term ERT users and young women. Cho reflects increased neuronal/glial membrane turnover. Thus, ERT's "neuroprotective" effect may include modulating the effects of age on neural integrity in brain regions involved in cognitive function.

M3 - Article

SN - 1526-632X

VL - 57

SP - 2114

EP - 2117

JO - Neurology

JF - Neurology

IS - 11

ER -