Abstract
We aimed to replicate previous effects of functional magnetic resonance imaging neurofeedback (fMRI-NF) in right inferior frontal cortex (rIFC) on IFC activation during a Stop Task in a larger group of boys with ADHD. The present double-blind, randomised controlled trial tested the effects of 15 runs of active versus sham fMRI-NF of rIFC on performance and activation associated with Successful and Failed Inhibition vs. Go trials during a tracking Stop Task in 88 boys with ADHD (44 active; 44 sham), controlling for age and medication status. No significant group by time interaction effects were observed for performance or brain activation during the successful stop trials, and post-hoc analysis showed very low numbers of active fMRI-NF learners. Nevertheless, during error monitoring, there was a significant group by time interaction effect on post-error reaction time slowing and in left IFC activation, which were both increased after active compared to sham fMRI-NF. The findings are in line with our previous observation of left IFC upregulation after fMRI-NF of rIFC relative to active fMRI-NF of parahippocampal gyrus. This highlights the potentially wider regional effects that fMRI-NF of a particular self-control target region has on other self-regulatory regions in ADHD.
| Original language | English |
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| Journal | Philosophical transactions of the Royal Society of London. Series B, Biological sciences |
| Publication status | Accepted/In press - 17 May 2024 |