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Effects of hemodiafiltration versus conventional hemodialysis in children with ESKD: The HDF, heart and height study

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Effects of hemodiafiltration versus conventional hemodialysis in children with ESKD : The HDF, heart and height study. / Shroff, Rukshana; Smith, Colette; Ranchin, Bruno; Bayazit, Aysun K.; Stefanidis, Constantinos J.; Askiti, Varvara; Azukaitis, Karolis; Canpolat, Nur; Agba, Ayşe; Aitkenhead, Helen; Anarat, Ali; Aoun, Bilal; Aofolaju, Daley; Bakkaloglu, Sevcan Azime; Bhowruth, Devina; Borzych-Duza, Dagmara; Bulut, Ipek Kaplan; Büscher, Rainer; Deanfield, John; Dempster, Claire; Duzova, Ali; Habbig, Sandra; Hayes, Wesley; Hegde, Shivram; Krid, Saoussen; Licht, Christoph; Litwin, Mieczyslaw; Mayes, Mark; Mir, Sevgi; Nemec, Rose; Obrycki, Lukasz; Paglialonga, Fabio; Picca, Stefano; Samaille, Charlotte; Shenoy, Mohan; Sinha, Manish D.; Spasojevic, Brankica; Stronach, Lynsey; Vidal, Enrico; Vondrák, Karel; Yilmaz, Alev; Zaloszyc, Ariane; Fischbach, Michel; Schmitt, Claus Peter; Schaefer, Franz.

In: Journal of the American Society of Nephrology, Vol. 30, No. 4, 01.04.2019, p. 678-691.

Research output: Contribution to journalArticle

Harvard

Shroff, R, Smith, C, Ranchin, B, Bayazit, AK, Stefanidis, CJ, Askiti, V, Azukaitis, K, Canpolat, N, Agba, A, Aitkenhead, H, Anarat, A, Aoun, B, Aofolaju, D, Bakkaloglu, SA, Bhowruth, D, Borzych-Duza, D, Bulut, IK, Büscher, R, Deanfield, J, Dempster, C, Duzova, A, Habbig, S, Hayes, W, Hegde, S, Krid, S, Licht, C, Litwin, M, Mayes, M, Mir, S, Nemec, R, Obrycki, L, Paglialonga, F, Picca, S, Samaille, C, Shenoy, M, Sinha, MD, Spasojevic, B, Stronach, L, Vidal, E, Vondrák, K, Yilmaz, A, Zaloszyc, A, Fischbach, M, Schmitt, CP & Schaefer, F 2019, 'Effects of hemodiafiltration versus conventional hemodialysis in children with ESKD: The HDF, heart and height study', Journal of the American Society of Nephrology, vol. 30, no. 4, pp. 678-691. https://doi.org/10.1681/ASN.2018100990

APA

Shroff, R., Smith, C., Ranchin, B., Bayazit, A. K., Stefanidis, C. J., Askiti, V., Azukaitis, K., Canpolat, N., Agba, A., Aitkenhead, H., Anarat, A., Aoun, B., Aofolaju, D., Bakkaloglu, S. A., Bhowruth, D., Borzych-Duza, D., Bulut, I. K., Büscher, R., Deanfield, J., ... Schaefer, F. (2019). Effects of hemodiafiltration versus conventional hemodialysis in children with ESKD: The HDF, heart and height study. Journal of the American Society of Nephrology, 30(4), 678-691. https://doi.org/10.1681/ASN.2018100990

Vancouver

Shroff R, Smith C, Ranchin B, Bayazit AK, Stefanidis CJ, Askiti V et al. Effects of hemodiafiltration versus conventional hemodialysis in children with ESKD: The HDF, heart and height study. Journal of the American Society of Nephrology. 2019 Apr 1;30(4):678-691. https://doi.org/10.1681/ASN.2018100990

Author

Shroff, Rukshana ; Smith, Colette ; Ranchin, Bruno ; Bayazit, Aysun K. ; Stefanidis, Constantinos J. ; Askiti, Varvara ; Azukaitis, Karolis ; Canpolat, Nur ; Agba, Ayşe ; Aitkenhead, Helen ; Anarat, Ali ; Aoun, Bilal ; Aofolaju, Daley ; Bakkaloglu, Sevcan Azime ; Bhowruth, Devina ; Borzych-Duza, Dagmara ; Bulut, Ipek Kaplan ; Büscher, Rainer ; Deanfield, John ; Dempster, Claire ; Duzova, Ali ; Habbig, Sandra ; Hayes, Wesley ; Hegde, Shivram ; Krid, Saoussen ; Licht, Christoph ; Litwin, Mieczyslaw ; Mayes, Mark ; Mir, Sevgi ; Nemec, Rose ; Obrycki, Lukasz ; Paglialonga, Fabio ; Picca, Stefano ; Samaille, Charlotte ; Shenoy, Mohan ; Sinha, Manish D. ; Spasojevic, Brankica ; Stronach, Lynsey ; Vidal, Enrico ; Vondrák, Karel ; Yilmaz, Alev ; Zaloszyc, Ariane ; Fischbach, Michel ; Schmitt, Claus Peter ; Schaefer, Franz. / Effects of hemodiafiltration versus conventional hemodialysis in children with ESKD : The HDF, heart and height study. In: Journal of the American Society of Nephrology. 2019 ; Vol. 30, No. 4. pp. 678-691.

Bibtex Download

@article{6241943abeff4542941ef056804cf7be,
title = "Effects of hemodiafiltration versus conventional hemodialysis in children with ESKD: The HDF, heart and height study",
abstract = "Background Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. Methods The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. Primary outcome measures were annualized changes in carotid intima-media thickness (cIMT) SD score and height SD score. Results We enrolled 190 children from 28 centers; 78 on HD and 55 on HDF completed 1-year follow-up. The groups were comparable for age, dialysis vintage, access type, dialysis frequency, blood flow, and residual renal function. At 1 year, cIMT SD score increased significantly in children on HD but remained static in the HDF cohort. On propensity score analysis, HD was associated with a +0.47 higher annualized cIMT SD score compared with HDF. Height SD score increased in HDF but remained static in HD. Mean arterial pressure SD score increased with HD only. Factors associated with higher cIMT and mean arterial pressure SD-scores were HD group, higher ultrafiltration rate, and higher b2-microglobulin. The HDF cohort had lower b2-microglobulin, parathyroid hormone, and high-sensitivity C-reactive protein at 1 year; fewer headaches, dizziness, or cramps; and shorter postdialysis recovery time. Conclusions HDF is associated with a lack of progression in vascular measures versus progression with HD, as well as an increase in height not seen in the HD cohort. Patient-related outcomes improved among children on HDF correlating with improved BP control and clearances. Confirmation through randomized trials is required.",
author = "Rukshana Shroff and Colette Smith and Bruno Ranchin and Bayazit, {Aysun K.} and Stefanidis, {Constantinos J.} and Varvara Askiti and Karolis Azukaitis and Nur Canpolat and Ay{\c s}e Agba and Helen Aitkenhead and Ali Anarat and Bilal Aoun and Daley Aofolaju and Bakkaloglu, {Sevcan Azime} and Devina Bhowruth and Dagmara Borzych-Duza and Bulut, {Ipek Kaplan} and Rainer B{\"u}scher and John Deanfield and Claire Dempster and Ali Duzova and Sandra Habbig and Wesley Hayes and Shivram Hegde and Saoussen Krid and Christoph Licht and Mieczyslaw Litwin and Mark Mayes and Sevgi Mir and Rose Nemec and Lukasz Obrycki and Fabio Paglialonga and Stefano Picca and Charlotte Samaille and Mohan Shenoy and Sinha, {Manish D.} and Brankica Spasojevic and Lynsey Stronach and Enrico Vidal and Karel Vondr{\'a}k and Alev Yilmaz and Ariane Zaloszyc and Michel Fischbach and Schmitt, {Claus Peter} and Franz Schaefer",
year = "2019",
month = apr,
day = "1",
doi = "10.1681/ASN.2018100990",
language = "English",
volume = "30",
pages = "678--691",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Effects of hemodiafiltration versus conventional hemodialysis in children with ESKD

T2 - The HDF, heart and height study

AU - Shroff, Rukshana

AU - Smith, Colette

AU - Ranchin, Bruno

AU - Bayazit, Aysun K.

AU - Stefanidis, Constantinos J.

AU - Askiti, Varvara

AU - Azukaitis, Karolis

AU - Canpolat, Nur

AU - Agba, Ayşe

AU - Aitkenhead, Helen

AU - Anarat, Ali

AU - Aoun, Bilal

AU - Aofolaju, Daley

AU - Bakkaloglu, Sevcan Azime

AU - Bhowruth, Devina

AU - Borzych-Duza, Dagmara

AU - Bulut, Ipek Kaplan

AU - Büscher, Rainer

AU - Deanfield, John

AU - Dempster, Claire

AU - Duzova, Ali

AU - Habbig, Sandra

AU - Hayes, Wesley

AU - Hegde, Shivram

AU - Krid, Saoussen

AU - Licht, Christoph

AU - Litwin, Mieczyslaw

AU - Mayes, Mark

AU - Mir, Sevgi

AU - Nemec, Rose

AU - Obrycki, Lukasz

AU - Paglialonga, Fabio

AU - Picca, Stefano

AU - Samaille, Charlotte

AU - Shenoy, Mohan

AU - Sinha, Manish D.

AU - Spasojevic, Brankica

AU - Stronach, Lynsey

AU - Vidal, Enrico

AU - Vondrák, Karel

AU - Yilmaz, Alev

AU - Zaloszyc, Ariane

AU - Fischbach, Michel

AU - Schmitt, Claus Peter

AU - Schaefer, Franz

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. Methods The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. Primary outcome measures were annualized changes in carotid intima-media thickness (cIMT) SD score and height SD score. Results We enrolled 190 children from 28 centers; 78 on HD and 55 on HDF completed 1-year follow-up. The groups were comparable for age, dialysis vintage, access type, dialysis frequency, blood flow, and residual renal function. At 1 year, cIMT SD score increased significantly in children on HD but remained static in the HDF cohort. On propensity score analysis, HD was associated with a +0.47 higher annualized cIMT SD score compared with HDF. Height SD score increased in HDF but remained static in HD. Mean arterial pressure SD score increased with HD only. Factors associated with higher cIMT and mean arterial pressure SD-scores were HD group, higher ultrafiltration rate, and higher b2-microglobulin. The HDF cohort had lower b2-microglobulin, parathyroid hormone, and high-sensitivity C-reactive protein at 1 year; fewer headaches, dizziness, or cramps; and shorter postdialysis recovery time. Conclusions HDF is associated with a lack of progression in vascular measures versus progression with HD, as well as an increase in height not seen in the HD cohort. Patient-related outcomes improved among children on HDF correlating with improved BP control and clearances. Confirmation through randomized trials is required.

AB - Background Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. Methods The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. Primary outcome measures were annualized changes in carotid intima-media thickness (cIMT) SD score and height SD score. Results We enrolled 190 children from 28 centers; 78 on HD and 55 on HDF completed 1-year follow-up. The groups were comparable for age, dialysis vintage, access type, dialysis frequency, blood flow, and residual renal function. At 1 year, cIMT SD score increased significantly in children on HD but remained static in the HDF cohort. On propensity score analysis, HD was associated with a +0.47 higher annualized cIMT SD score compared with HDF. Height SD score increased in HDF but remained static in HD. Mean arterial pressure SD score increased with HD only. Factors associated with higher cIMT and mean arterial pressure SD-scores were HD group, higher ultrafiltration rate, and higher b2-microglobulin. The HDF cohort had lower b2-microglobulin, parathyroid hormone, and high-sensitivity C-reactive protein at 1 year; fewer headaches, dizziness, or cramps; and shorter postdialysis recovery time. Conclusions HDF is associated with a lack of progression in vascular measures versus progression with HD, as well as an increase in height not seen in the HD cohort. Patient-related outcomes improved among children on HDF correlating with improved BP control and clearances. Confirmation through randomized trials is required.

UR - http://www.scopus.com/inward/record.url?scp=85063960868&partnerID=8YFLogxK

U2 - 10.1681/ASN.2018100990

DO - 10.1681/ASN.2018100990

M3 - Article

C2 - 30846560

AN - SCOPUS:85063960868

VL - 30

SP - 678

EP - 691

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 4

ER -

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