Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans

TY - JOUR

T1 - Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans

AU - Stewart, A D

AU - Millasseau, S C

AU - Kearney, M T

AU - Ritter, J M

AU - Chowienczyk, P J

PY - 2003/11

Y1 - 2003/11

N2 - Aortic stiffness, as measured by carotid-femoral pulse wave velocity (PWV), is a powerful, independent predictor of vascular risk. PWV in muscular arteries is influenced by basal nitric oxide (NO) release. It is not known whether NO also influences carotid-femoral PWV. We examined the effects of an NO synthase inhibitor, N-G-monomethyl-L-arginine (L-NMMA), on carotid-femoral PWV and aortic augmentation index (AIx, an indirect measure of arterial stiffness). To control for effects of L-NMMA on distending pressure, we used doses of norepinephrine and dobutamine that caused similar changes in mean arterial blood pressure (MAP). Healthy men (32 to 48 years old, n=8) were studied on 4 occasions and received, in random order, vehicle, L-NMMA (3 mg.kg(-1) by intravenous bolus followed by 3 mg.kg(-1).h(-1)), norepinephrine (50 ng.kg(-1).min(-1)), and dobutamine (2.5 to 10 mug.kg(-1).min(-1)), each for 30 minutes. PWV and AIx were measured by carotid-femoral PWV and radial tonometry, respectively. L-NMMA and norepinephrine increased MAP by 7.8+/-1.7 and 9.7+/-2.1 mm Hg, respectively (each P0.99, P

AB - Aortic stiffness, as measured by carotid-femoral pulse wave velocity (PWV), is a powerful, independent predictor of vascular risk. PWV in muscular arteries is influenced by basal nitric oxide (NO) release. It is not known whether NO also influences carotid-femoral PWV. We examined the effects of an NO synthase inhibitor, N-G-monomethyl-L-arginine (L-NMMA), on carotid-femoral PWV and aortic augmentation index (AIx, an indirect measure of arterial stiffness). To control for effects of L-NMMA on distending pressure, we used doses of norepinephrine and dobutamine that caused similar changes in mean arterial blood pressure (MAP). Healthy men (32 to 48 years old, n=8) were studied on 4 occasions and received, in random order, vehicle, L-NMMA (3 mg.kg(-1) by intravenous bolus followed by 3 mg.kg(-1).h(-1)), norepinephrine (50 ng.kg(-1).min(-1)), and dobutamine (2.5 to 10 mug.kg(-1).min(-1)), each for 30 minutes. PWV and AIx were measured by carotid-femoral PWV and radial tonometry, respectively. L-NMMA and norepinephrine increased MAP by 7.8+/-1.7 and 9.7+/-2.1 mm Hg, respectively (each P0.99, P

UR - http://www.scopus.com/inward/record.url?scp=0242441513&partnerID=8YFLogxK

U2 - 10.1161/01.HYP.0000092882.65699.19

DO - 10.1161/01.HYP.0000092882.65699.19

M3 - Article

VL - 42

SP - 915

EP - 918

JO - Hypertension

JF - Hypertension

IS - 5

ER -