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Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study

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Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study. / Tavazzi, Eleonora; Bergsland, Niels; Cattaneo, Davide; Gervasoni, Elisa; Lagana', Maria Marcella; Dipasquale, Ottavia; Grosso, Cristina; Saibene, Francesca Lea; Baglio, Francesca; Rovaris, Marco.

In: Journal of Neurology, 2018.

Research output: Contribution to journalArticle

Harvard

Tavazzi, E, Bergsland, N, Cattaneo, D, Gervasoni, E, Lagana', MM, Dipasquale, O, Grosso, C, Saibene, FL, Baglio, F & Rovaris, M 2018, 'Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study', Journal of Neurology. https://doi.org/10.1007/s00415-018-8859-y

APA

Tavazzi, E., Bergsland, N., Cattaneo, D., Gervasoni, E., Lagana', M. M., Dipasquale, O., ... Rovaris, M. (2018). Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study. Journal of Neurology. https://doi.org/10.1007/s00415-018-8859-y

Vancouver

Tavazzi E, Bergsland N, Cattaneo D, Gervasoni E, Lagana' MM, Dipasquale O et al. Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study. Journal of Neurology. 2018. https://doi.org/10.1007/s00415-018-8859-y

Author

Tavazzi, Eleonora ; Bergsland, Niels ; Cattaneo, Davide ; Gervasoni, Elisa ; Lagana', Maria Marcella ; Dipasquale, Ottavia ; Grosso, Cristina ; Saibene, Francesca Lea ; Baglio, Francesca ; Rovaris, Marco. / Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study. In: Journal of Neurology. 2018.

Bibtex Download

@article{39a0f0d1f35642068d4e8c76366eaa75,
title = "Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study",
abstract = "Background Rehabilitation seems to promote brain plasticity, but objective measures of efcacy are lacking and there is alimited understanding of the mechanisms underlying functional recovery.Objective To study functional and structural brain changes induced by gait rehabilitation.Methods We enrolled MS inpatients (EDSS 4.5–6.5) undergoing a 4-week neurorehabilitation. Several clinical measureswere obtained, including: 2-min walk test (2MWT), dynamic gait index (DGI), Berg balance scale (BBS). Furthermore,motor-task functional MRI (fMRI) of plantar dorsifexion, resting state fMRI, and regional difusion tensor imaging (DTI)metrics were obtained. All the assessments were performed at baseline (T0), after the end of the rehabilitation period (T1)and 3 months later (T2).Results Twenty-nine patients were enrolled at T0, 26 at T1, and 16 completed all timepoints. At T1, there was a signifcantimprovement of 2MWT, DGI, and BBS scores, along with a reduced extent of the widespread activation related to the motortask at the fMRI and an increased functional connectivity in the precentral and post-central gyrus, bilaterally. None of thesechanges were maintained at T2.Conclusions Our fndings show a short-term benefcial efect of motor rehabilitation on gait performances in MS, accompanied by brain functional reorganization in the sensory-motor network.",
author = "Eleonora Tavazzi and Niels Bergsland and Davide Cattaneo and Elisa Gervasoni and Lagana', {Maria Marcella} and Ottavia Dipasquale and Cristina Grosso and Saibene, {Francesca Lea} and Francesca Baglio and Marco Rovaris",
year = "2018",
doi = "10.1007/s00415-018-8859-y",
language = "English",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study

AU - Tavazzi, Eleonora

AU - Bergsland, Niels

AU - Cattaneo, Davide

AU - Gervasoni, Elisa

AU - Lagana', Maria Marcella

AU - Dipasquale, Ottavia

AU - Grosso, Cristina

AU - Saibene, Francesca Lea

AU - Baglio, Francesca

AU - Rovaris, Marco

PY - 2018

Y1 - 2018

N2 - Background Rehabilitation seems to promote brain plasticity, but objective measures of efcacy are lacking and there is alimited understanding of the mechanisms underlying functional recovery.Objective To study functional and structural brain changes induced by gait rehabilitation.Methods We enrolled MS inpatients (EDSS 4.5–6.5) undergoing a 4-week neurorehabilitation. Several clinical measureswere obtained, including: 2-min walk test (2MWT), dynamic gait index (DGI), Berg balance scale (BBS). Furthermore,motor-task functional MRI (fMRI) of plantar dorsifexion, resting state fMRI, and regional difusion tensor imaging (DTI)metrics were obtained. All the assessments were performed at baseline (T0), after the end of the rehabilitation period (T1)and 3 months later (T2).Results Twenty-nine patients were enrolled at T0, 26 at T1, and 16 completed all timepoints. At T1, there was a signifcantimprovement of 2MWT, DGI, and BBS scores, along with a reduced extent of the widespread activation related to the motortask at the fMRI and an increased functional connectivity in the precentral and post-central gyrus, bilaterally. None of thesechanges were maintained at T2.Conclusions Our fndings show a short-term benefcial efect of motor rehabilitation on gait performances in MS, accompanied by brain functional reorganization in the sensory-motor network.

AB - Background Rehabilitation seems to promote brain plasticity, but objective measures of efcacy are lacking and there is alimited understanding of the mechanisms underlying functional recovery.Objective To study functional and structural brain changes induced by gait rehabilitation.Methods We enrolled MS inpatients (EDSS 4.5–6.5) undergoing a 4-week neurorehabilitation. Several clinical measureswere obtained, including: 2-min walk test (2MWT), dynamic gait index (DGI), Berg balance scale (BBS). Furthermore,motor-task functional MRI (fMRI) of plantar dorsifexion, resting state fMRI, and regional difusion tensor imaging (DTI)metrics were obtained. All the assessments were performed at baseline (T0), after the end of the rehabilitation period (T1)and 3 months later (T2).Results Twenty-nine patients were enrolled at T0, 26 at T1, and 16 completed all timepoints. At T1, there was a signifcantimprovement of 2MWT, DGI, and BBS scores, along with a reduced extent of the widespread activation related to the motortask at the fMRI and an increased functional connectivity in the precentral and post-central gyrus, bilaterally. None of thesechanges were maintained at T2.Conclusions Our fndings show a short-term benefcial efect of motor rehabilitation on gait performances in MS, accompanied by brain functional reorganization in the sensory-motor network.

U2 - 10.1007/s00415-018-8859-y

DO - 10.1007/s00415-018-8859-y

M3 - Article

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

ER -

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