Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene

C. Murgatroyd; J. P. Quinn; H. M. Sharp; A. Pickles; J. Hill

doi:10.1038/tp.2014.140

Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene

C. Murgatroyd, J. P. Quinn, H. M. Sharp, A. Pickles, J. Hill^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

143 Citations (Scopus)

Abstract

In animal models, prenatal and postnatal stress is associated with elevated hypothalamic-pituitary axis (HPA) reactivity mediated via altered glucocorticoid receptor (GR) gene expression. Postnatal tactile stimulation is associated with reduced HPA reactivity mediated via increased GR gene expression. In this first study in humans to examine the joint effects of prenatal and postnatal environmental exposures, we report that GR gene (NR3C1) 1-F promoter methylation in infants is elevated in the presence of increased maternal postnatal depression following low prenatal depression, and that this effect is reversed by self-reported stroking of the infants by their mothers over the first weeks of life.

Original language	English
Article number	e560
Journal	Translational psychiatry
Volume	5
DOIs	https://doi.org/10.1038/tp.2014.140
Publication status	Published - 5 May 2015

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10.1038/tp.2014.140

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AU - Hill, J.

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Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene

Abstract

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