@article{0717fb32efba4fd8afb5360c23cfffb6,
title = "Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis",
abstract = "Background/Objectives:: Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. The aim of the current network meta-analysis (NMA) was to evaluate the efficacy and acceptability of different NIBS modalities for weight reduction in participants with obesity. Methods:: Randomized controlled trials (RCTs) examining NIBS interventions in patients with obesity were analyzed using the frequentist model of NMA. The coprimary outcome was change in body mass index (BMI) and acceptability, which was calculated using the dropout rate. Results:: Overall, the current NMA, consisting of eight RCTs, revealed that the high-frequency repetitive transcranial magnetic stimulation (TMS) over the left DLPFC was ranked to be associated with the second-largest decrease in BMI and the largest decrease in total energy intake and craving severity, whereas the high-frequency deep TMS over bilateral DLPFC and the insula was ranked to be associated with the largest decrease in BMI. Conclusion:: This pilot study provided a “signal” for the design of more methodologically robust and larger RCTs based on the findings of the potentially beneficial effect on weight reduction in participants with obesity by different NIBS interventions.",
author = "Zeng, {Bing Yan} and Zeng, {Bing Syuan} and Chen, {Yen Wen} and Hung, {Chao Ming} and Sun, {Cheuk Kwan} and Cheng, {Yu Shian} and Brendon Stubbs and Carvalho, {Andre F.} and Brunoni, {Andre R.} and Su, {Kuan Pin} and Tu, {Yu Kang} and Wu, {Yi Cheng} and Chen, {Tien Yu} and Lin, {Pao Yen} and Liang, {Chih Sung} and Hsu, {Chih Wei} and Tseng, {Ping Tao} and Li, {Cheng Ta}",
note = "Funding Information: Acknowledgements The authors of this work were supported by the following grants: Brendon Stubbs is supported by a Clinical Lectureship (ICA-CL-2017-03-001) jointly funded by Health Education England (HEE) and the National Institute for Health Research (NIHR). Brendon Stubbs is part-funded by the NIHR Biomedical Research Center at South London and Maudsley NHS Foundation Trust. Brendon Stubbs is also supported by the Maudsley Charity, King{\textquoteright}s College London, and the NIHR South London Collaboration for Leadership in Applied Health Research and Care (CLAHRC) funding. This paper presents independent research. The views expressed in this publication are those of the authors and not necessarily those of the acknowledged institutions. The work of Kuan-Pin Su is supported by the following grants: MOST 106-2314-B-039-027-MY3, 107-2314-B-039-005, 108-2320-B-039-048, and 108-2314-B-039-016 from the Ministry of Science and Technology, Taiwan; and DMR-107-091, DRM-108-091, CRS-108-048, CMU108-SR-106, DMR-108-216, CMRC-CMA-3, DMR-109-102 and the Chinese Medicine Research Center from the China Medical University, Taiwan. The work by Pao-Yen Lin is supported by the following grants: MOST 106-2314-B-182A-085 -MY2 and MOST 105-2314-B-182A-057 from the Ministry of Science and Technology, Taiwan; and CMRPG8F1371, CMRPG8E1061F from Kaohsiung Chang Gung Memorial Hospital, Taiwan. The work of Yu-Kang Tu was supported by a grant from the Ministry of Science and Technology, Taiwan (grant no: 106‐2314‐B‐ 002 ‐098 ‐MY3). Dr Brunoni reports grants from S{\~a}o Paulo Research State Foundation (2012/20911-5, 2017/50223-6, 2018/10861-7), Brazilian National Council of Scientific Development productivity support (PQ-1B), and University of S{\~a}o Paulo Medical School productivity support (PIPA-A), during the conduct of the study; personal fees from Neurocare GMBH outside the submitted work; and Dr. Brunoni is Chief Medical Advisor of Flow Neuroscience (Malm{\"o}, Sweden) and has small equity in this company. This role started in June 2019. This manuscript was edited by Elsevier Language Editing Services. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature Limited. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = aug,
doi = "10.1038/s41366-021-00833-2",
language = "English",
volume = "45",
pages = "1705--1716",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Springer Nature [academic journals on nature.com]",
number = "8",
}
