Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands

David J Berry; Yongmin Ma; James R Ballinger; Richard Tavaré; Alexander Koers; Kavitha Sunassee; Tao Zhou; Saima Nawaz; Gregory E D Mullen; Robert C Hider; Philip J Blower

doi:10.1039/c1cc12123e

Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands

David J Berry, Yongmin Ma, James R Ballinger, Richard Tavaré, Alexander Koers, Kavitha Sunassee, Tao Zhou, Saima Nawaz, Gregory E D Mullen, Robert C Hider, Philip J Blower

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120 Citations (Scopus)

Abstract

A new tripodal tris(hydroxypyridinone) bifunctional chelator for gallium allows easy production of Ga-68-labelled proteins rapidly under mild conditions in high yields at exceptionally high specific activity and low concentration.

Original language	English
Pages (from-to)	7068 - 7070
Number of pages	3
Journal	CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY
Volume	47
Issue number	25
DOIs	https://doi.org/10.1039/c1cc12123e
Publication status	Published - 7 Jul 2011

Keywords

Animals
Chelating Agents
Cross-Linking Reagents
Gallium Radioisotopes
Humans
Ligands
Mice
Positron-Emission Tomography
Pyridones
Synaptotagmin I

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10.1039/c1cc12123e

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Berry, D. J., Ma, Y., Ballinger, J. R., Tavaré, R., Koers, A., Sunassee, K., Zhou, T., Nawaz, S., Mullen, G. E. D., Hider, R. C., & Blower, P. J. (2011). Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands. CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY, 47(25), 7068 - 7070. https://doi.org/10.1039/c1cc12123e

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AU - Sunassee, Kavitha

AU - Zhou, Tao

AU - Nawaz, Saima

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AU - Hider, Robert C

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KW - Positron-Emission Tomography

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Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands

Abstract

Keywords

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