Efficient Synthesis of 11C-Acrylesters, 11C-Acrylamides and Their Application in Michael Addition Reactions for PET Tracer Development

Ulrike Filp*, Anna L. Pees, Carlotta Taddei, Aleksandra Pekošak, Antony D. Gee, Albert D. Windhorst, Alex J. Poot

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Here we present a new Michael addition reaction utilizing carbon-11 labeled acrylic esters and amides. Subsequently, reactions of these synthons with commercially available Schiff base precursors are performed to produce [11C]glutamate and [11C]glutamine. This methodology is especially useful for the development of positron emission tomography (PET) imaging agents as it offers a new array of potential carbon-11 labeled compounds with this original 11C–C bond forming strategy.

Original languageEnglish
Pages (from-to)5154-5162
Number of pages9
JournalEUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume2017
Issue number34
Early online date14 Sept 2017
DOIs
Publication statusPublished - 15 Sept 2017

Keywords

  • Amino acids
  • Carbonylation
  • Michael addition
  • Positron emission tomography
  • Radiochemistry
  • Schiff bases

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