EFSA International Workshop on RA of Combined Exposure to Multiple Chemicals

Jean-Lou CM Dorne; Christer Hogstrand; Bruno Dujardin; George EN Kass; AK Djien Liem; Jose Tarazona; Kyriaki Machera; Tobin Robinson; Paola Manini; Emilio Benfenati; Jan Dirk te Biesebeek; Josef Schlatter; Paul Price; Patience Browne; Alan R Boobis; Angelo Moretto; Anthony Smith; Emanuela Testai; Antonio Hernández-Jerez; Susanne Hougaard-Bennekou; Vittorio Fattori; Stephanie Bopp; Heather Wallace

doi:10.2903/sp.efsa.2022.EN-7422

EFSA International Workshop on RA of Combined Exposure to Multiple Chemicals

Jean-Lou CM Dorne, Christer Hogstrand, Bruno Dujardin, George EN Kass, AK Djien Liem, Jose Tarazona, Kyriaki Machera, Tobin Robinson, Paola Manini, Emilio Benfenati, Jan Dirk te Biesebeek, Josef Schlatter, Paul Price, Patience Browne, Alan R Boobis, Angelo Moretto, Anthony Smith, Emanuela Testai, Antonio Hernández-Jerez, Susanne Hougaard-BennekouVittorio Fattori, Stephanie Bopp, Heather Wallace

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract Human Risk Assessment (RA) of combined exposure to multiple chemicals follows the steps of RA namely problem formulation, exposure assessment, hazard assessment and risk characterisation. Over the last decade, scientific advisory bodies have published a range of harmonised guidance documents to provide practical approaches for risk assessors. These include the WHO, the US-EPA, the Joint Research Centre (JRC) of the European Commission, the OECD and the recent EFSA MIXTOX guidance document dealing with harmonised methodologies for the human health, animal health and ecological RA areas. On May 21st 2021, the Scientific Committee of EFSA published a draft guidance document on scientific criteria to group chemicals in assessment groups using hazard-driven criteria and prioritisation methods using exposure-driven and risk-based approaches. The latter guidance and future challenges were the topic of this international workshop which was held online in the afternoons of the 18th, 19th and 20st October 2021. First, a plenary session provided overviews of European and international activities in the field including WHO, OECD, US-EPA, JRC and EFSA. With a total of 118 participants including national and international scientific advisory bodies, academics and researchers, NGOs, industry, risk assessors, risk managers, four discussions groups were created for three break-out group sessions: 1) Hazard-driven criteria for grouping multiple chemicals into assessment groups; 2) Exposure-driven and risk-based criteria for the prioritisation of multiple chemicals 3) Data gaps and future challenges for human health and environmental RA of combined exposure to multiple chemicals to identify priority topics of international relevance and a way forward to address these topics. A final discussion and wrap-up session concluded the meeting. This event report provides a summary of the discussions together with conclusions and recommendations.

Original language	English
Pages (from-to)	7422E
Journal	EFSA Supporting Publications
Volume	19
Issue number	7
DOIs	https://doi.org/10.2903/sp.efsa.2022.EN-7422
Publication status	Published - 2022

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10.2903/sp.efsa.2022.EN-7422

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Dorne, J.-L. CM., Hogstrand, C., Dujardin, B., Kass, G. EN., Liem, AK. D., Tarazona, J., Machera, K., Robinson, T., Manini, P., Benfenati, E., te Biesebeek, J. D., Schlatter, J., Price, P., Browne, P., Boobis, A. R., Moretto, A., Smith, A., Testai, E., Hernández-Jerez, A., ... Wallace, H. (2022). EFSA International Workshop on RA of Combined Exposure to Multiple Chemicals. EFSA Supporting Publications, 19(7), 7422E. https://doi.org/10.2903/sp.efsa.2022.EN-7422

@article{77eca5b0a294431aa3071f16333af80b,

title = "EFSA International Workshop on RA of Combined Exposure to Multiple Chemicals",

abstract = "Abstract Human Risk Assessment (RA) of combined exposure to multiple chemicals follows the steps of RA namely problem formulation, exposure assessment, hazard assessment and risk characterisation. Over the last decade, scientific advisory bodies have published a range of harmonised guidance documents to provide practical approaches for risk assessors. These include the WHO, the US-EPA, the Joint Research Centre (JRC) of the European Commission, the OECD and the recent EFSA MIXTOX guidance document dealing with harmonised methodologies for the human health, animal health and ecological RA areas. On May 21st 2021, the Scientific Committee of EFSA published a draft guidance document on scientific criteria to group chemicals in assessment groups using hazard-driven criteria and prioritisation methods using exposure-driven and risk-based approaches. The latter guidance and future challenges were the topic of this international workshop which was held online in the afternoons of the 18th, 19th and 20st October 2021. First, a plenary session provided overviews of European and international activities in the field including WHO, OECD, US-EPA, JRC and EFSA. With a total of 118 participants including national and international scientific advisory bodies, academics and researchers, NGOs, industry, risk assessors, risk managers, four discussions groups were created for three break-out group sessions: 1) Hazard-driven criteria for grouping multiple chemicals into assessment groups; 2) Exposure-driven and risk-based criteria for the prioritisation of multiple chemicals 3) Data gaps and future challenges for human health and environmental RA of combined exposure to multiple chemicals to identify priority topics of international relevance and a way forward to address these topics. A final discussion and wrap-up session concluded the meeting. This event report provides a summary of the discussions together with conclusions and recommendations.",

author = "Dorne, {Jean-Lou CM} and Christer Hogstrand and Bruno Dujardin and Kass, {George EN} and Liem, {AK Djien} and Jose Tarazona and Kyriaki Machera and Tobin Robinson and Paola Manini and Emilio Benfenati and {te Biesebeek}, {Jan Dirk} and Josef Schlatter and Paul Price and Patience Browne and Boobis, {Alan R} and Angelo Moretto and Anthony Smith and Emanuela Testai and Antonio Hern{\'a}ndez-Jerez and Susanne Hougaard-Bennekou and Vittorio Fattori and Stephanie Bopp and Heather Wallace",

year = "2022",

doi = "10.2903/sp.efsa.2022.EN-7422",

language = "English",

volume = "19",

pages = "7422E",

journal = "EFSA Supporting Publications",

issn = "2397-8325",

publisher = "John Wiley & Sons, Ltd",

number = "7",

}

Dorne, J-LCM, Hogstrand, C, Dujardin, B, Kass, GEN, Liem, AKD, Tarazona, J, Machera, K, Robinson, T, Manini, P, Benfenati, E, te Biesebeek, JD, Schlatter, J, Price, P, Browne, P, Boobis, AR, Moretto, A, Smith, A, Testai, E, Hernández-Jerez, A, Hougaard-Bennekou, S, Fattori, V, Bopp, S & Wallace, H 2022, 'EFSA International Workshop on RA of Combined Exposure to Multiple Chemicals', EFSA Supporting Publications, vol. 19, no. 7, pp. 7422E. https://doi.org/10.2903/sp.efsa.2022.EN-7422

TY - JOUR

T1 - EFSA International Workshop on RA of Combined Exposure to Multiple Chemicals

AU - Dorne, Jean-Lou CM

AU - Hogstrand, Christer

AU - Dujardin, Bruno

AU - Kass, George EN

AU - Liem, AK Djien

AU - Tarazona, Jose

AU - Machera, Kyriaki

AU - Robinson, Tobin

AU - Manini, Paola

AU - Benfenati, Emilio

AU - te Biesebeek, Jan Dirk

AU - Schlatter, Josef

AU - Price, Paul

AU - Browne, Patience

AU - Boobis, Alan R

AU - Moretto, Angelo

AU - Smith, Anthony

AU - Testai, Emanuela

AU - Hernández-Jerez, Antonio

AU - Hougaard-Bennekou, Susanne

AU - Fattori, Vittorio

AU - Bopp, Stephanie

AU - Wallace, Heather

PY - 2022

Y1 - 2022

N2 - Abstract Human Risk Assessment (RA) of combined exposure to multiple chemicals follows the steps of RA namely problem formulation, exposure assessment, hazard assessment and risk characterisation. Over the last decade, scientific advisory bodies have published a range of harmonised guidance documents to provide practical approaches for risk assessors. These include the WHO, the US-EPA, the Joint Research Centre (JRC) of the European Commission, the OECD and the recent EFSA MIXTOX guidance document dealing with harmonised methodologies for the human health, animal health and ecological RA areas. On May 21st 2021, the Scientific Committee of EFSA published a draft guidance document on scientific criteria to group chemicals in assessment groups using hazard-driven criteria and prioritisation methods using exposure-driven and risk-based approaches. The latter guidance and future challenges were the topic of this international workshop which was held online in the afternoons of the 18th, 19th and 20st October 2021. First, a plenary session provided overviews of European and international activities in the field including WHO, OECD, US-EPA, JRC and EFSA. With a total of 118 participants including national and international scientific advisory bodies, academics and researchers, NGOs, industry, risk assessors, risk managers, four discussions groups were created for three break-out group sessions: 1) Hazard-driven criteria for grouping multiple chemicals into assessment groups; 2) Exposure-driven and risk-based criteria for the prioritisation of multiple chemicals 3) Data gaps and future challenges for human health and environmental RA of combined exposure to multiple chemicals to identify priority topics of international relevance and a way forward to address these topics. A final discussion and wrap-up session concluded the meeting. This event report provides a summary of the discussions together with conclusions and recommendations.

AB - Abstract Human Risk Assessment (RA) of combined exposure to multiple chemicals follows the steps of RA namely problem formulation, exposure assessment, hazard assessment and risk characterisation. Over the last decade, scientific advisory bodies have published a range of harmonised guidance documents to provide practical approaches for risk assessors. These include the WHO, the US-EPA, the Joint Research Centre (JRC) of the European Commission, the OECD and the recent EFSA MIXTOX guidance document dealing with harmonised methodologies for the human health, animal health and ecological RA areas. On May 21st 2021, the Scientific Committee of EFSA published a draft guidance document on scientific criteria to group chemicals in assessment groups using hazard-driven criteria and prioritisation methods using exposure-driven and risk-based approaches. The latter guidance and future challenges were the topic of this international workshop which was held online in the afternoons of the 18th, 19th and 20st October 2021. First, a plenary session provided overviews of European and international activities in the field including WHO, OECD, US-EPA, JRC and EFSA. With a total of 118 participants including national and international scientific advisory bodies, academics and researchers, NGOs, industry, risk assessors, risk managers, four discussions groups were created for three break-out group sessions: 1) Hazard-driven criteria for grouping multiple chemicals into assessment groups; 2) Exposure-driven and risk-based criteria for the prioritisation of multiple chemicals 3) Data gaps and future challenges for human health and environmental RA of combined exposure to multiple chemicals to identify priority topics of international relevance and a way forward to address these topics. A final discussion and wrap-up session concluded the meeting. This event report provides a summary of the discussions together with conclusions and recommendations.

U2 - 10.2903/sp.efsa.2022.EN-7422

DO - 10.2903/sp.efsa.2022.EN-7422

M3 - Article

SN - 2397-8325

VL - 19

SP - 7422E

JO - EFSA Supporting Publications

JF - EFSA Supporting Publications

IS - 7

ER -

EFSA International Workshop on RA of Combined Exposure to Multiple Chemicals

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