Electrochemical [11C]CO2 to [11C]CO conversion for PET imaging

David A. Anders; Salvatore Bongarzone; Robin Fortt; Antony D. Gee; Nicholas J. Long

doi:10.1039/c7cc00319f

Electrochemical [¹¹C]CO₂ to [¹¹C]CO conversion for PET imaging

David A. Anders
, Salvatore Bongarzone
, Robin Fortt
, Antony D. Gee^*
, Nicholas J. Long

^*Corresponding author for this work

Fédération d'anesthésiologie-réanimation et de médecine hyperbare, hôpital d'instruction des armées du Val-de-Grâce, 75005 Paris, France; Inserm U676, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMRS 676, 75013 Paris, France; Centre for the Developing Brain, Department of Perinatal Imaging and Health, King's College London, London, Royaume-Uni. Electronic address: [email protected].
Imperial College London

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([¹¹C]CO) from cyclotron-produced carbon-11 carbon dioxide ([¹¹C]CO₂) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [¹¹C]CO from [¹¹C]CO₂. Produced [¹¹C]CO was subsequently converted to [¹¹C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.

Original language	English
Pages (from-to)	2982-2985
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	53
Issue number	20
Early online date	24 Feb 2017
DOIs	https://doi.org/10.1039/c7cc00319f
Publication status	Published - 2017

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abstract = "The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10\% yields of [11C]CO from [11C]CO2. Produced [11C]CO was subsequently converted to [11C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98\%.",

author = "Anders, \{David A.\} and Salvatore Bongarzone and Robin Fortt and Gee, \{Antony D.\} and Long, \{Nicholas J.\}",

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AU - Anders, David A.

AU - Bongarzone, Salvatore

AU - Fortt, Robin

AU - Gee, Antony D.

AU - Long, Nicholas J.

PY - 2017

Y1 - 2017

N2 - The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [11C]CO from [11C]CO2. Produced [11C]CO was subsequently converted to [11C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.

AB - The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [11C]CO from [11C]CO2. Produced [11C]CO was subsequently converted to [11C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.

UR - https://www.scopus.com/pages/publications/85014693181

U2 - 10.1039/c7cc00319f

DO - 10.1039/c7cc00319f

M3 - Article

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SN - 1359-7345

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SP - 2982

EP - 2985

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 20

ER -

Electrochemical [¹¹C]CO₂ to [¹¹C]CO conversion for PET imaging

Abstract

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