Electrostatic catalysis of a click reaction in a microfluidic cell

TY - JOUR

T1 - Electrostatic catalysis of a click reaction in a microfluidic cell

AU - Sevim, Semih

AU - Sanchis-Gual, Roger

AU - Franco, Carlos

AU - Aragonès, Albert C.

AU - Darwish, Nadim

AU - Kim, Donghoon

AU - Picca, Rosaria Anna

AU - Nelson, Bradley J.

AU - Ruiz, Eliseo

AU - Pané, Salvador

AU - Díez-Pérez, Ismael

AU - Puigmartí-Luis, Josep

N1 - Funding Information: This work is supported by European Union’s Horizon Europe Research and Innovation Programme under EVA project (GA No: 101047081, JPL, SP); European Research Council Consolidator Grant Fields4CAT ERC−2019-CoG 772391 (IDP); Swiss National Science Foundation 200021_181988 (JPL); MCIN/ AEI /10.13039/501100011033 PID2020-116612RB-C33 (JPL); 2021 SGR 00270 (JPL); PID2021-122464NB-I00 (ER); CEX2021-001202-M (ER, JPL); ICREA Academia (ER). Partial support from SNSF-Sinergia project no:198643 (BJN) is also acknowledged. S.P. acknowledges the Swiss State Secretariat for Education, Research and Innovation (SERI). IDP acknowledges financial support from the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) under the grant agreement BB/X002810/1. Funding Information: This work is supported by European Union’s Horizon Europe Research and Innovation Programme under EVA project (GA No: 101047081, JPL, SP); European Research Council Consolidator Grant Fields4CAT ERC−2019-CoG 772391 (IDP); Swiss National Science Foundation 200021_181988 (JPL); MCIN/ AEI /10.13039/501100011033 PID2020-116612RB-C33 (JPL); 2021 SGR 00270 (JPL); PID2021-122464NB-I00 (ER); CEX2021-001202-M (ER, JPL); ICREA Academia (ER). Partial support from SNSF-Sinergia project no:198643 (BJN) is also acknowledged. S.P. acknowledges the Swiss State Secretariat for Education, Research and Innovation (SERI). IDP acknowledges financial support from the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) under the grant agreement BB/X002810/1. Publisher Copyright: © 2024, The Author(s).

PY - 2024/1/26

Y1 - 2024/1/26

N2 - Electric fields have been highlighted as a smart reagent in nature’s enzymatic machinery, as they can directly trigger or accelerate chemical processes with stereo- and regio-specificity. In enzymatic catalysis, controlled mass transport of chemical species is also key in facilitating the availability of reactants in the active reaction site. However, recent progress in developing a clean catalysis that profits from oriented electric fields is limited to theoretical and experimental studies at the single molecule level, where both the control over mass transport and scalability cannot be tested. Here, we quantify the electrostatic catalysis of a prototypical Huisgen cycloaddition in a large-area electrode surface and directly compare its performance to the conventional Cu(I) catalysis. Our custom-built microfluidic cell enhances reagent transport towards the electrified reactive interface. This continuous-flow microfluidic electrostatic reactor is an example of an electric-field driven platform where clean large-scale electrostatic catalytic processes can be efficiently implemented and regulated.

AB - Electric fields have been highlighted as a smart reagent in nature’s enzymatic machinery, as they can directly trigger or accelerate chemical processes with stereo- and regio-specificity. In enzymatic catalysis, controlled mass transport of chemical species is also key in facilitating the availability of reactants in the active reaction site. However, recent progress in developing a clean catalysis that profits from oriented electric fields is limited to theoretical and experimental studies at the single molecule level, where both the control over mass transport and scalability cannot be tested. Here, we quantify the electrostatic catalysis of a prototypical Huisgen cycloaddition in a large-area electrode surface and directly compare its performance to the conventional Cu(I) catalysis. Our custom-built microfluidic cell enhances reagent transport towards the electrified reactive interface. This continuous-flow microfluidic electrostatic reactor is an example of an electric-field driven platform where clean large-scale electrostatic catalytic processes can be efficiently implemented and regulated.

UR - http://www.scopus.com/inward/record.url?scp=85183343029&partnerID=8YFLogxK

U2 - 10.1038/s41467-024-44716-2

DO - 10.1038/s41467-024-44716-2

M3 - Article

C2 - 38278792

SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 790

ER -