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Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk Mechanism for Psychosis

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Alice Egerton ; Oliver D Howes ; Sylvain Houle ; Kwame McKenzie ; Lucia R Valmaggia ; Michael R Bagby ; Huai-Hsuan Tseng ; Michael A P Bloomfield ; Miran Kenk ; Sagnik Bhattacharyya ; Ivonne Suridjan ; Chistopher A Chaddock ; Toby T Winton-Brown ; Paul Allen ; Pablo Rusjan ; Gary Remington ; Andreas Meyer-Lindenberg ; Philip K McGuire ; Romina Mizrahi

Original languageEnglish
Pages (from-to)293–301
Number of pages9
JournalSchizophrenia Bulletin
Volume43
Issue number2
Early online date5 Jan 2017
DOIs
StatePublished - 1 Mar 2017

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Abstract

Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism is through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether striatal dopamine function is elevated in immigrants compared to nonimmigrants and the relationship with psychosis. Two complementary case-control studies of in vivo dopamine function (stress-induced dopamine release and dopamine synthesis capacity) in immigrants compared to nonimmigrants were performed in Canada and the United Kingdom. The Canadian dopamine release study included 25 immigrant and 31 nonmigrant Canadians. These groups included 23 clinical high risk (CHR) subjects, 9 antipsychotic naïve patients with schizophrenia, and 24 healthy volunteers. The UK dopamine synthesis study included 32 immigrants and 44 nonimmigrant British. These groups included 50 CHR subjects and 26 healthy volunteers. Both striatal stress-induced dopamine release and dopamine synthesis capacity were significantly elevated in immigrants compared to nonimmigrants, independent of clinical status. These data provide the first evidence that the effect of migration on the risk of developing psychosis may be mediated by an elevation in brain dopamine function.

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