TY - JOUR
T1 - Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis
T2 - A combined voxel-based morphometry and voxel-based cortical thickness study
AU - Benetti, Stefania
AU - Pettersson-Yeo, William
AU - Hutton, Chloe
AU - Catani, Marco
AU - Williams, Steven C.R.
AU - Allen, Paul
AU - Kambeitz-Ilankovic, Lana M.
AU - McGuire, Philip
AU - Mechelli, Andrea
PY - 2013/11
Y1 - 2013/11
N2 - Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. Because these studies have typically focused on either grey matter volume or cortical thickness separately, the relationship between these two types of alterations is currently unclear. In the present investigation we used both voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) to examine neuroanatomical differences in 21 individuals with an At Risk Mental State (ARMS) for psychosis, 26 patients with a First Episode of Psychosis (FEP) and 24 healthy controls. Statistical inferences were made at P <0.05 after correction for multiple comparisons. Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability. In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease. These neuroanatomical differences were expressed in terms of cortical thickness but not in terms of grey matter volume, and therefore may reflect specific cortical atrophy as opposed to variations in sulcal and gyral morphology.
AB - Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. Because these studies have typically focused on either grey matter volume or cortical thickness separately, the relationship between these two types of alterations is currently unclear. In the present investigation we used both voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) to examine neuroanatomical differences in 21 individuals with an At Risk Mental State (ARMS) for psychosis, 26 patients with a First Episode of Psychosis (FEP) and 24 healthy controls. Statistical inferences were made at P <0.05 after correction for multiple comparisons. Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability. In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease. These neuroanatomical differences were expressed in terms of cortical thickness but not in terms of grey matter volume, and therefore may reflect specific cortical atrophy as opposed to variations in sulcal and gyral morphology.
KW - First Episode Psychosis
KW - At Risk Mental State
KW - VBM
KW - Cortical thickness
KW - Imaging
KW - GRAY-MATTER
KW - 1ST-EPISODE SCHIZOPHRENIA
KW - ONSET SCHIZOPHRENIA
KW - ABNORMALITIES
KW - PREVENTION
KW - PREDICTION
KW - MRI
KW - Acknowledged-BRC
KW - Acknowledged-BRC-13/14
U2 - 10.1016/j.schres.2013.08.030
DO - 10.1016/j.schres.2013.08.030
M3 - Article
SN - 0920-9964
VL - 150
SP - 505
EP - 511
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2-3
M1 - N/A
ER -