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Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Research output: Contribution to journalReview article

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Emergence of 3D Printed Dosage Forms : Opportunities and Challenges. / Alhnan, Mohamed A; Okwuosa, Tochukwu C; Sadia, Muzna; Wan, Ka-Wai; Ahmed, Waqar; Arafat, Basel.

In: Pharmaceutical Research, Vol. 33, No. 8, 08.2016, p. 1817-1832.

Research output: Contribution to journalReview article

Harvard

Alhnan, MA, Okwuosa, TC, Sadia, M, Wan, K-W, Ahmed, W & Arafat, B 2016, 'Emergence of 3D Printed Dosage Forms: Opportunities and Challenges', Pharmaceutical Research, vol. 33, no. 8, pp. 1817-1832. https://doi.org/10.1007/s11095-016-1933-1

APA

Alhnan, M. A., Okwuosa, T. C., Sadia, M., Wan, K-W., Ahmed, W., & Arafat, B. (2016). Emergence of 3D Printed Dosage Forms: Opportunities and Challenges. Pharmaceutical Research, 33(8), 1817-1832. https://doi.org/10.1007/s11095-016-1933-1

Vancouver

Alhnan MA, Okwuosa TC, Sadia M, Wan K-W, Ahmed W, Arafat B. Emergence of 3D Printed Dosage Forms: Opportunities and Challenges. Pharmaceutical Research. 2016 Aug;33(8):1817-1832. https://doi.org/10.1007/s11095-016-1933-1

Author

Alhnan, Mohamed A ; Okwuosa, Tochukwu C ; Sadia, Muzna ; Wan, Ka-Wai ; Ahmed, Waqar ; Arafat, Basel. / Emergence of 3D Printed Dosage Forms : Opportunities and Challenges. In: Pharmaceutical Research. 2016 ; Vol. 33, No. 8. pp. 1817-1832.

Bibtex Download

@article{144317205a54489f94bcb3866b855d8c,
title = "Emergence of 3D Printed Dosage Forms: Opportunities and Challenges",
abstract = "The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such an extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.",
keywords = "Dosage Forms, Drug Compounding/methods, Humans, Precision Medicine/trends, Printing, Three-Dimensional/trends, Tablets, Technology, Pharmaceutical/methods",
author = "Alhnan, {Mohamed A} and Okwuosa, {Tochukwu C} and Muzna Sadia and Ka-Wai Wan and Waqar Ahmed and Basel Arafat",
year = "2016",
month = aug,
doi = "10.1007/s11095-016-1933-1",
language = "English",
volume = "33",
pages = "1817--1832",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer New York",
number = "8",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Emergence of 3D Printed Dosage Forms

T2 - Opportunities and Challenges

AU - Alhnan, Mohamed A

AU - Okwuosa, Tochukwu C

AU - Sadia, Muzna

AU - Wan, Ka-Wai

AU - Ahmed, Waqar

AU - Arafat, Basel

PY - 2016/8

Y1 - 2016/8

N2 - The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such an extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

AB - The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such an extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

KW - Dosage Forms

KW - Drug Compounding/methods

KW - Humans

KW - Precision Medicine/trends

KW - Printing, Three-Dimensional/trends

KW - Tablets

KW - Technology, Pharmaceutical/methods

U2 - 10.1007/s11095-016-1933-1

DO - 10.1007/s11095-016-1933-1

M3 - Review article

C2 - 27194002

VL - 33

SP - 1817

EP - 1832

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 8

ER -

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