Emergencies in Acute Myopathies: Acute Toxic Myopathies, Rhabdomyolysis, and Malignant Hyperthermia

Benedikt Schoser*, Heinz Jungbluth*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Acute toxic myopathies, rhabdomyolysis, and malignant hyperthermia involve all muscles massively in parallel, and at the same time. They are key emergency sequels related to neuromuscular disorders, often their first manifestation and uncovering. Plenty of drugs, infections, and metabolic defects lead to rhabdomyolysis; however, only a limited number of impacts such as a skeletal muscle ryanodine receptor (RYR1) gene mutation can lead to malignant hyperthermia. Clinical recognition is most important in all those situations. This review focuses on the fundamentals of abnormal changes related to acute toxic myopathies, rhabdomyolysis, and the evolution of malignant hyperthermia. This review tries to provide practical answers with cases taken from the authors’ clinical practice, illustrating bedside judgment and interpretation of additional laboratory tests.

Original languageEnglish
Title of host publicationEmergencies in Neuromuscular Disorders
PublisherSpringer International Publishing
Number of pages16
ISBN (Electronic)9783030919320
ISBN (Print)9783030919313
Publication statusPublished - 1 Jan 2022


  • Creatine kinase
  • Malignant hyperthermia
  • Rhabdomyolysis
  • Toxic myopathies


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