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Emergent properties of the optic tectum revealed by population analysis of direction and orientation selectivity

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Emergent properties of the optic tectum revealed by population analysis of direction and orientation selectivity. / Hunter, Paul R; Lowe, Andrew S; Thompson, Ian et al.

In: Journal of Neuroscience, Vol. 33, No. 35, 28.08.2013, p. 13940-13945.

Research output: Contribution to journalArticlepeer-review

Harvard

Hunter, PR, Lowe, AS, Thompson, I & Meyer, MP 2013, 'Emergent properties of the optic tectum revealed by population analysis of direction and orientation selectivity', Journal of Neuroscience, vol. 33, no. 35, pp. 13940-13945. https://doi.org/10.1523/JNEUROSCI.1493-13.2013

APA

Hunter, P. R., Lowe, A. S., Thompson, I., & Meyer, M. P. (2013). Emergent properties of the optic tectum revealed by population analysis of direction and orientation selectivity. Journal of Neuroscience, 33(35), 13940-13945. https://doi.org/10.1523/JNEUROSCI.1493-13.2013

Vancouver

Hunter PR, Lowe AS, Thompson I, Meyer MP. Emergent properties of the optic tectum revealed by population analysis of direction and orientation selectivity. Journal of Neuroscience. 2013 Aug 28;33(35):13940-13945. https://doi.org/10.1523/JNEUROSCI.1493-13.2013

Author

Hunter, Paul R ; Lowe, Andrew S ; Thompson, Ian et al. / Emergent properties of the optic tectum revealed by population analysis of direction and orientation selectivity. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 35. pp. 13940-13945.

Bibtex Download

@article{db2f13ad56ed4fffaef0d77c9436192c,
title = "Emergent properties of the optic tectum revealed by population analysis of direction and orientation selectivity",
abstract = "How local circuits within the brain process visual information has classically been addressed at the single neuron level. Such reductionist approaches, however, struggle to capture the full scope of functional properties associated with even {"}simple{"} brain nuclei. Using population functional calcium imaging, we aim to describe how local circuits within the zebrafish optic tectum process visual information. Specifically, how are previously identified direction-selective (DS) and orientation-selective (OS) retinal ganglion cell (RGC) inputs (Nikolaou et al., 2012) represented in tectal cells? First, we identify an emergent population of DS tectal cell with a direction preference not explicitly present in any one of the RGC inputs. Second, this is associated with a striking shift from a tiled and triangular representation of directional space (RGC inputs) into an overlapping cardinal representation by tectal cell populations. Third, and in contrast, we find that orientation space is represented similarly in both the RGC input and tectal cell populations illustrating feature-dependent differences in how tectal circuits process their inputs. Finally, we identify OS and two populations of DS cells at the superficial border of the tectal neuropil, one of which is an emergent population. This study, together with our previous one (Nikolaou et al., 2012), demonstrate that direction-selectivity is established in both the retina and tectum.",
author = "Hunter, {Paul R} and Lowe, {Andrew S} and Ian Thompson and Meyer, {Martin P}",
year = "2013",
month = aug,
day = "28",
doi = "10.1523/JNEUROSCI.1493-13.2013",
language = "English",
volume = "33",
pages = "13940--13945",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "35",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Emergent properties of the optic tectum revealed by population analysis of direction and orientation selectivity

AU - Hunter, Paul R

AU - Lowe, Andrew S

AU - Thompson, Ian

AU - Meyer, Martin P

PY - 2013/8/28

Y1 - 2013/8/28

N2 - How local circuits within the brain process visual information has classically been addressed at the single neuron level. Such reductionist approaches, however, struggle to capture the full scope of functional properties associated with even "simple" brain nuclei. Using population functional calcium imaging, we aim to describe how local circuits within the zebrafish optic tectum process visual information. Specifically, how are previously identified direction-selective (DS) and orientation-selective (OS) retinal ganglion cell (RGC) inputs (Nikolaou et al., 2012) represented in tectal cells? First, we identify an emergent population of DS tectal cell with a direction preference not explicitly present in any one of the RGC inputs. Second, this is associated with a striking shift from a tiled and triangular representation of directional space (RGC inputs) into an overlapping cardinal representation by tectal cell populations. Third, and in contrast, we find that orientation space is represented similarly in both the RGC input and tectal cell populations illustrating feature-dependent differences in how tectal circuits process their inputs. Finally, we identify OS and two populations of DS cells at the superficial border of the tectal neuropil, one of which is an emergent population. This study, together with our previous one (Nikolaou et al., 2012), demonstrate that direction-selectivity is established in both the retina and tectum.

AB - How local circuits within the brain process visual information has classically been addressed at the single neuron level. Such reductionist approaches, however, struggle to capture the full scope of functional properties associated with even "simple" brain nuclei. Using population functional calcium imaging, we aim to describe how local circuits within the zebrafish optic tectum process visual information. Specifically, how are previously identified direction-selective (DS) and orientation-selective (OS) retinal ganglion cell (RGC) inputs (Nikolaou et al., 2012) represented in tectal cells? First, we identify an emergent population of DS tectal cell with a direction preference not explicitly present in any one of the RGC inputs. Second, this is associated with a striking shift from a tiled and triangular representation of directional space (RGC inputs) into an overlapping cardinal representation by tectal cell populations. Third, and in contrast, we find that orientation space is represented similarly in both the RGC input and tectal cell populations illustrating feature-dependent differences in how tectal circuits process their inputs. Finally, we identify OS and two populations of DS cells at the superficial border of the tectal neuropil, one of which is an emergent population. This study, together with our previous one (Nikolaou et al., 2012), demonstrate that direction-selectivity is established in both the retina and tectum.

U2 - 10.1523/JNEUROSCI.1493-13.2013

DO - 10.1523/JNEUROSCI.1493-13.2013

M3 - Article

C2 - 23986231

VL - 33

SP - 13940

EP - 13945

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 35

ER -

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