Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate

Silvia Camporesi*, Giulia Cavaliere

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)
362 Downloads (Pure)

Abstract

This paper provides an overview of the ethical issues in the international clustered regularly interspaced short palindromic repeats (CRISPR) genome editing debate from March 2015 to September 2016. We present the regulatory framework for embryo research in the UK, and explain why CRISPR is not a significant break with the past. We discuss the ethical issues arising from CRISPR applications beyond human embryos, namely the use of gene drive-engineered mosquitoes to eradicate diseases, engineering nonhuman animals to harvest organs for human transplant and engineering crops. We discuss the experiments that have demonstrated the technical feasibility of cultivating embryos in vitro for up to 14 days, and possibly beyond this limit, and the ethical issues arising from the proposal to extend the limit beyond 14 days.
Original languageEnglish
Pages (from-to)575-586
Number of pages12
JournalFuture Medicine
Volume13
Issue number6
Early online date28 Oct 2016
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • Genome Editing
  • CRISPR
  • bioethics
  • HUMAN EMBRYOS
  • genomics
  • CRISPR/Cas9

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