Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia

Peter Taggart; Esther Pueyo; Stefan van Duijvenboden; Bradley Porter; Martin Bishop; David A. Sampedro-Puente; M. Orini; B. Hanson; Christopher A. Rinaldi; Jaswinder S. Gill; Pier Lambiase

doi:10.1093/europace/euab009

Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia

Peter Taggart, Esther Pueyo, Stefan van Duijvenboden, Bradley Porter, Martin Bishop, David A. Sampedro-Puente, M. Orini, B. Hanson, Christopher A. Rinaldi, Jaswinder S. Gill, Pier Lambiase

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Strong recent clinical evidence links the presence of prominent oscillations of ventricular repolarization in the low-frequency range (0.04-0.15 Hz) to the incidence of ventricular arrhythmia and sudden death in post-MI patients and patients with ischaemic and non-ischaemic cardiomyopathy. It has been proposed that these oscillations reflect oscillations of ventricular action potential duration at the sympathetic nerve frequency. Here we review emerging evidence to support that contention and provide insight into possible underlying mechanisms for this association.

Original language	English
Pages (from-to)	1350-1358
Number of pages	9
Journal	Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Volume	23
Issue number	9
DOIs	https://doi.org/10.1093/europace/euab009
Publication status	Published - 8 Sept 2021

Keywords

Action potential duration
Arrhythmia
Beta-adrenergic stimulation
Electrophysiology
Low-frequency oscillations
Mechano-electric feedback
Repolarization
T wave

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10.1093/europace/euab009

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Taggart, P., Pueyo, E., Duijvenboden, S. V., Porter, B., Bishop, M., Sampedro-Puente, D. A., Orini, M., Hanson, B., Rinaldi, C. A., Gill, J. S., & Lambiase, P. (2021). Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 23(9), 1350-1358. https://doi.org/10.1093/europace/euab009

Taggart, Peter ; Pueyo, Esther ; Duijvenboden, Stefan van et al. / Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia. In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2021 ; Vol. 23, No. 9. pp. 1350-1358.

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title = "Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia",

abstract = "Strong recent clinical evidence links the presence of prominent oscillations of ventricular repolarization in the low-frequency range (0.04-0.15 Hz) to the incidence of ventricular arrhythmia and sudden death in post-MI patients and patients with ischaemic and non-ischaemic cardiomyopathy. It has been proposed that these oscillations reflect oscillations of ventricular action potential duration at the sympathetic nerve frequency. Here we review emerging evidence to support that contention and provide insight into possible underlying mechanisms for this association.",

keywords = "Action potential duration, Arrhythmia, Beta-adrenergic stimulation, Electrophysiology, Low-frequency oscillations, Mechano-electric feedback, Repolarization, T wave",

author = "Peter Taggart and Esther Pueyo and Duijvenboden, {Stefan van} and Bradley Porter and Martin Bishop and Sampedro-Puente, {David A.} and M. Orini and B. Hanson and Rinaldi, {Christopher A.} and Gill, {Jaswinder S.} and Pier Lambiase",

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doi = "10.1093/europace/euab009",

language = "English",

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journal = "Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology",

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Taggart, P, Pueyo, E, Duijvenboden, SV, Porter, B , Bishop, M, Sampedro-Puente, DA, Orini, M, Hanson, B, Rinaldi, CA, Gill, JS & Lambiase, P 2021, 'Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia', Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 23, no. 9, pp. 1350-1358. https://doi.org/10.1093/europace/euab009

Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia. / Taggart, Peter; Pueyo, Esther; Duijvenboden, Stefan van et al.
In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Vol. 23, No. 9, 08.09.2021, p. 1350-1358.

Research output: Contribution to journal › Review article › peer-review

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AU - Pueyo, Esther

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AU - Porter, Bradley

AU - Bishop, Martin

AU - Sampedro-Puente, David A.

AU - Orini, M.

AU - Hanson, B.

AU - Rinaldi, Christopher A.

AU - Gill, Jaswinder S.

AU - Lambiase, Pier

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N2 - Strong recent clinical evidence links the presence of prominent oscillations of ventricular repolarization in the low-frequency range (0.04-0.15 Hz) to the incidence of ventricular arrhythmia and sudden death in post-MI patients and patients with ischaemic and non-ischaemic cardiomyopathy. It has been proposed that these oscillations reflect oscillations of ventricular action potential duration at the sympathetic nerve frequency. Here we review emerging evidence to support that contention and provide insight into possible underlying mechanisms for this association.

AB - Strong recent clinical evidence links the presence of prominent oscillations of ventricular repolarization in the low-frequency range (0.04-0.15 Hz) to the incidence of ventricular arrhythmia and sudden death in post-MI patients and patients with ischaemic and non-ischaemic cardiomyopathy. It has been proposed that these oscillations reflect oscillations of ventricular action potential duration at the sympathetic nerve frequency. Here we review emerging evidence to support that contention and provide insight into possible underlying mechanisms for this association.

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KW - Beta-adrenergic stimulation

KW - Electrophysiology

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KW - Mechano-electric feedback

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JF - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

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ER -

Taggart P, Pueyo E, Duijvenboden SV, Porter B , Bishop M, Sampedro-Puente DA et al. Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2021 Sept 8;23(9):1350-1358. doi: 10.1093/europace/euab009

Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia

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