Emerging functions of alternative splicing coupled with nonsense-mediated decay

TY - JOUR

T1 - Emerging functions of alternative splicing coupled with nonsense-mediated decay

AU - Hamid, Fursham

AU - Makeyev, Evgeniy

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cytoplasmic quality control mechanism eliminating mRNAs containing PTCs (premature translation termination codons). Although originally identified as an error surveillance process, AS-NMD additionally provides an efficient strategy for deterministic regulation of gene expression outputs. In this review, we discuss recently published examples of AS-NMD and delineate functional contexts where recurrent use of this mechanism orchestrates expression of important genes.

AB - Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cytoplasmic quality control mechanism eliminating mRNAs containing PTCs (premature translation termination codons). Although originally identified as an error surveillance process, AS-NMD additionally provides an efficient strategy for deterministic regulation of gene expression outputs. In this review, we discuss recently published examples of AS-NMD and delineate functional contexts where recurrent use of this mechanism orchestrates expression of important genes.

U2 - 10.1042/BST20140066

DO - 10.1042/BST20140066

M3 - Literature review

SN - 0300-5127

VL - 42

SP - 1168

EP - 1173

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -