Emerging molecular pathways governing dietary regulation of neural stem cells during aging

TY - JOUR

T1 - Emerging molecular pathways governing dietary regulation of neural stem cells during aging

AU - de Lucia, Chiara

AU - Murphy, Tytus

AU - Thuret, Sandrine

PY - 2017/1/30

Y1 - 2017/1/30

N2 - Aging alters cellular and molecular processes, including those of stem cells biology. In particular, changes in neural stem cells (NSCs) are linked to cognitive decline associated with aging. Recently, the systemic environment has been shown to alter both NSCs regulation and age-related cognitive decline. Interestingly, a well-documented and naturally occurring way of altering the composition of the systemic environment is through diet and nutrition. Furthermore, it is well established that the presence of specific nutrients as well as the overall increase or reduction of calorie intake can modulate conserved molecular pathways and respectively reduce or increase lifespan. In this review, we examine these pathways in relation to their function on NSCs and cognitive aging. We highlight the importance of the Sirtuin, mTOR and Insulin/Insulin like growth factor-1 pathways as well as the significant role played by epigenetics in the dietary regulation of NSCs and the need for further research to exploit nutrition as a mode of intervention to regulate NSCs aging.

AB - Aging alters cellular and molecular processes, including those of stem cells biology. In particular, changes in neural stem cells (NSCs) are linked to cognitive decline associated with aging. Recently, the systemic environment has been shown to alter both NSCs regulation and age-related cognitive decline. Interestingly, a well-documented and naturally occurring way of altering the composition of the systemic environment is through diet and nutrition. Furthermore, it is well established that the presence of specific nutrients as well as the overall increase or reduction of calorie intake can modulate conserved molecular pathways and respectively reduce or increase lifespan. In this review, we examine these pathways in relation to their function on NSCs and cognitive aging. We highlight the importance of the Sirtuin, mTOR and Insulin/Insulin like growth factor-1 pathways as well as the significant role played by epigenetics in the dietary regulation of NSCs and the need for further research to exploit nutrition as a mode of intervention to regulate NSCs aging.

KW - Aging

KW - Diet

KW - Epigenetics

KW - IIS

KW - Insulin-like growth factor signaling

KW - MTOR

KW - Nutrients

KW - Sirtuins

UR - http://www.scopus.com/inward/record.url?scp=85011826930&partnerID=8YFLogxK

U2 - 10.3389/fphys.2017.00017

DO - 10.3389/fphys.2017.00017

M3 - Article

AN - SCOPUS:85011826930

SN - 1664-042X

VL - 8

JO - Frontiers in Physiology

JF - Frontiers in Physiology

IS - JAN

M1 - 17

ER -