Emerging molecular targets in melanoma invasion and metastasis

TY - JOUR

T1 - Emerging molecular targets in melanoma invasion and metastasis

AU - Orgaz, Jose L.

AU - Sanz Moreno, Vicky

PY - 2013/1

Y1 - 2013/1

N2 - Metastatic cutaneous melanoma accounts for the majority of skin cancer deaths due to its aggressiveness and high resistance to current therapies. To efficiently metastasize, invasive melanoma cells need to change their cytoskeletal organization and alter contacts with the extracellular matrix and the surrounding stromal cells. Melanoma cells can use different migratory strategies depending on varying environments to exit the primary tumour mass and invade surrounding and later distant tissues. In this review, we have focused on tumour cell plasticity or the interconvertibility that melanoma cells have as one of the factors that contribute to melanoma metastasis. This has been an area of very intense research in the last 5 yr yielding a vast number of findings. We have therefore reviewed all the possible clinical opportunities that this new knowledge offers to both stratify and treat cutaneous malignant melanoma patients.

AB - Metastatic cutaneous melanoma accounts for the majority of skin cancer deaths due to its aggressiveness and high resistance to current therapies. To efficiently metastasize, invasive melanoma cells need to change their cytoskeletal organization and alter contacts with the extracellular matrix and the surrounding stromal cells. Melanoma cells can use different migratory strategies depending on varying environments to exit the primary tumour mass and invade surrounding and later distant tissues. In this review, we have focused on tumour cell plasticity or the interconvertibility that melanoma cells have as one of the factors that contribute to melanoma metastasis. This has been an area of very intense research in the last 5 yr yielding a vast number of findings. We have therefore reviewed all the possible clinical opportunities that this new knowledge offers to both stratify and treat cutaneous malignant melanoma patients.

KW - molecular targets

KW - melanoma

KW - invasion

KW - metastasis

KW - anticancer therapy

KW - plasticity

KW - CUTANEOUS MALIGNANT-MELANOMA

KW - RECEPTOR TYROSINE KINASES

KW - FIBROBLAST-GROWTH-FACTOR

KW - SRC FAMILY KINASES

KW - COLLECTIVE CELL-MIGRATION

KW - NF2 TUMOR-SUPPRESSOR

KW - V600E B-RAF

KW - BETA-CATENIN

KW - IN-VIVO

KW - TRANSCRIPTION FACTOR

U2 - 10.1111/pcmr.12041

DO - 10.1111/pcmr.12041

M3 - Literature review

SN - 1755-1471

VL - 26

SP - 39

EP - 57

JO - Pigment cell & melanoma research

JF - Pigment cell & melanoma research

IS - 1

M1 - N/A

ER -