Emerging molecular targets in melanoma invasion and metastasis

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78 Citations (Scopus)

Abstract

Metastatic cutaneous melanoma accounts for the majority of skin cancer deaths due to its aggressiveness and high resistance to current therapies. To efficiently metastasize, invasive melanoma cells need to change their cytoskeletal organization and alter contacts with the extracellular matrix and the surrounding stromal cells. Melanoma cells can use different migratory strategies depending on varying environments to exit the primary tumour mass and invade surrounding and later distant tissues. In this review, we have focused on tumour cell plasticity or the interconvertibility that melanoma cells have as one of the factors that contribute to melanoma metastasis. This has been an area of very intense research in the last 5 yr yielding a vast number of findings. We have therefore reviewed all the possible clinical opportunities that this new knowledge offers to both stratify and treat cutaneous malignant melanoma patients.

Original languageEnglish
Article numberN/A
Pages (from-to)39-57
Number of pages19
JournalPigment cell & melanoma research
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • molecular targets
  • melanoma
  • invasion
  • metastasis
  • anticancer therapy
  • plasticity
  • CUTANEOUS MALIGNANT-MELANOMA
  • RECEPTOR TYROSINE KINASES
  • FIBROBLAST-GROWTH-FACTOR
  • SRC FAMILY KINASES
  • COLLECTIVE CELL-MIGRATION
  • NF2 TUMOR-SUPPRESSOR
  • V600E B-RAF
  • BETA-CATENIN
  • IN-VIVO
  • TRANSCRIPTION FACTOR

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