Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid-Based Nanoparticles

TY - JOUR

T1 - Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid-Based Nanoparticles

AU - Fernandes, Soraia

AU - Cassani, Marco

AU - Cavalieri, Francesca

AU - Forte, Giancarlo

AU - Caruso, Frank

N1 - Publisher Copyright: © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

PY - 2024/2/23

Y1 - 2024/2/23

N2 - The application of lipid-based nanoparticles for COVID-19 vaccines and transthyretin-mediated amyloidosis treatment have highlighted their potential for translation to cancer therapy. However, their use in delivering drugs to solid tumors is limited by ineffective targeting, heterogeneous organ distribution, systemic inflammatory responses, and insufficient drug accumulation at the tumor. Instead, the use of lipid-based nanoparticles to remotely activate immune system responses is an emerging effective strategy. Despite this approach showing potential for treating hematological cancers, its application to treat solid tumors is hampered by the selection of eligible targets, tumor heterogeneity, and ineffective penetration of activated T cells within the tumor. Notwithstanding, the use of lipid-based nanoparticles for immunotherapy is projected to revolutionize cancer therapy, with the ultimate goal of rendering cancer a chronic disease. However, the translational success is likely to depend on the use of predictive tumor models in preclinical studies, simulating the complexity of the tumor microenvironment (e.g., the fibrotic extracellular matrix that impairs therapeutic outcomes) and stimulating tumor progression. This review compiles recent advances in the field of antitumor lipid-based nanoparticles and highlights emerging therapeutic approaches (e.g., mechanotherapy) to modulate tumor stiffness and improve T cell infiltration, and the use of organoids to better guide therapeutic outcomes.

AB - The application of lipid-based nanoparticles for COVID-19 vaccines and transthyretin-mediated amyloidosis treatment have highlighted their potential for translation to cancer therapy. However, their use in delivering drugs to solid tumors is limited by ineffective targeting, heterogeneous organ distribution, systemic inflammatory responses, and insufficient drug accumulation at the tumor. Instead, the use of lipid-based nanoparticles to remotely activate immune system responses is an emerging effective strategy. Despite this approach showing potential for treating hematological cancers, its application to treat solid tumors is hampered by the selection of eligible targets, tumor heterogeneity, and ineffective penetration of activated T cells within the tumor. Notwithstanding, the use of lipid-based nanoparticles for immunotherapy is projected to revolutionize cancer therapy, with the ultimate goal of rendering cancer a chronic disease. However, the translational success is likely to depend on the use of predictive tumor models in preclinical studies, simulating the complexity of the tumor microenvironment (e.g., the fibrotic extracellular matrix that impairs therapeutic outcomes) and stimulating tumor progression. This review compiles recent advances in the field of antitumor lipid-based nanoparticles and highlights emerging therapeutic approaches (e.g., mechanotherapy) to modulate tumor stiffness and improve T cell infiltration, and the use of organoids to better guide therapeutic outcomes.

KW - Humans

KW - COVID-19 Vaccines

KW - Immunotherapy

KW - Neoplasms/therapy

KW - Amyloid Neuropathies, Familial

KW - Lipids

KW - Tumor Microenvironment

UR - https://www.scopus.com/pages/publications/85178441062

U2 - 10.1002/advs.202305769

DO - 10.1002/advs.202305769

M3 - Review article

C2 - 38054651

AN - SCOPUS:85178441062

SN - 2198-3844

VL - 11

JO - Advanced Science

JF - Advanced Science

IS - 8

M1 - 2305769

ER -