Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medication

TY - JOUR

T1 - Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medication

AU - Surguladze, Simon A.

AU - Chu, Elvina M.

AU - Marshall, Nicolette

AU - Evans, Anthony

AU - Anilkumar, Anantha P. P.

AU - Timehin, Clive

AU - McDonald, Colm

AU - Ecker, Christine

AU - Phillips, Mary L.

AU - David, Anthony S.

PY - 2011/6

Y1 - 2011/6

N2 - We employed two event-related functional magnetic resonance imaging tasks using the pictures of mild and intense facial emotions of fear or happiness. The sample comprised 16 chronic schizophrenia patients treated with risperidone long-acting injections (RLAI), 16 patients treated with conventional antipsychotic depots (CONV) and 16 healthy controls (HC). The HC and RLAI groups demonstrated greater activation in the left amygdala in response to intensively fearful faces, and in right cerebellum to intensively happy faces compared with CONV patients. The CONV group demonstrated under-activation in the right temporal pole in response to intensively happy faces (compared with HC) and over-activation in ventro-medial prefrontal cortex (VMPFC) in response to both intensively happy and fearful expressions, compared with HC and RLAI groups. Our results suggest that networks implicated in the allocation of attentional resources (VMPFC) and emotion processing (amygdala, cerebellum) are differentially affected in patients on CONV versus RLAI.

AB - We employed two event-related functional magnetic resonance imaging tasks using the pictures of mild and intense facial emotions of fear or happiness. The sample comprised 16 chronic schizophrenia patients treated with risperidone long-acting injections (RLAI), 16 patients treated with conventional antipsychotic depots (CONV) and 16 healthy controls (HC). The HC and RLAI groups demonstrated greater activation in the left amygdala in response to intensively fearful faces, and in right cerebellum to intensively happy faces compared with CONV patients. The CONV group demonstrated under-activation in the right temporal pole in response to intensively happy faces (compared with HC) and over-activation in ventro-medial prefrontal cortex (VMPFC) in response to both intensively happy and fearful expressions, compared with HC and RLAI groups. Our results suggest that networks implicated in the allocation of attentional resources (VMPFC) and emotion processing (amygdala, cerebellum) are differentially affected in patients on CONV versus RLAI.

U2 - 10.1177/0269881110363316

DO - 10.1177/0269881110363316

M3 - Article

SN - 1461-7285

VL - 25

SP - 722

EP - 733

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

IS - 6

ER -