End-Diastolic and End-Systolic LV Morphology in the Presence of Cardiovascular Risk Factors: A UK Biobank Study

Kathleen Gilbert*, Avan Suinesiaputra, Stefan Neubauer, Stefan Piechnik, Nay Aung, Steffen E. Petersen, Alistair Young

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

Abstract

Left ventricular function and morphology have been shown to be important factors in clinical and pre-clinical cardiovascular disease. In this paper we used atlas-based techniques to capture the full extent of morphological changes at end-diastole, end-systole and in a coupled functional atlas for 4547 UK Biobank participants. The morphological differences between participants with risk factors for cardiovascular disease were tested using a logistic regression model. The result was compared to a model built from traditional mass and volume measures, and the strength of associations were tested using a Delong’s test. Atlas based models had stronger associations with risk factors than mass and volume parameters in most risk factors. The functional atlas showed better performance than the separate end-diastole and end-systole atlases.

Original languageEnglish
Title of host publicationFunctional Imaging and Modeling of the Heart - 10th International Conference, FIMH 2019, Proceedings
EditorsYves Coudière, Nejib Zemzemi, Valéry Ozenne, Edward Vigmond
PublisherSpringer Verlag
Pages304-312
Number of pages9
ISBN (Print)9783030219482
DOIs
Publication statusE-pub ahead of print - 30 May 2019
Event10th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2019 - Bordeaux, France
Duration: 6 Jun 20198 Jun 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11504 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference10th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2019
Country/TerritoryFrance
CityBordeaux
Period6/06/20198/06/2019

Keywords

  • Cardiac atlases
  • Cardiac MRI
  • Cardiovascular risk factors

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