End-tidal carbon monoxide levels in prematurely born infants developing bronchopulmonary dysplasia

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Bronchopulmonary dysplasia (BPD) is associated with an early inflammatory response that persists after the first week of life. Inflammatory mediators can induce hemoxygenase-1 with a consequent increase in carbon monoxide (CO) production. End-tidal CO (ETCO) levels would be elevated in infants developing BPD. Serial measurements of ETCO levels were attempted on d 3, 5, 7, 14, 21, and 28 in 50 prematurely born infants (median gestational age 29 wk). Fourteen infants developed BPD [oxygen dependent beyond 36 wk post-menstrual age (PMA)] and had higher ETCO levels compared with the rest of the cohort on d 7, 14, 21, and 28. On d 14, the mean (SD) ETCO levels of the BPD group were 3.19 (1.11) ppm and 1.43 (0.61) ppm in the non-BPD group (p2.15 ppm had a sensitivity of 80% and specificity of 92% in predicting oxygen dependency at 36 wk PMA. Measurement of ETCO levels in prematurely born infants may be useful in the prediction of BPD.
Original languageEnglish
Pages (from-to)474 - 478
Number of pages5
JournalPediatric Research
Issue number4
Publication statusPublished - Apr 2007


  • Bronchopulmonary Dysplasia
  • Humans
  • Exhalation
  • Infant, Newborn
  • Carbon Monoxide
  • Infant, Premature
  • Male
  • Female


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