Endocannabinoid Turnover

Christopher J. Fowler; Patrick Doherty; Stephen P.H. Alexander

doi:10.1016/bs.apha.2017.03.006

Endocannabinoid Turnover

Christopher J. Fowler, Patrick Doherty, Stephen P.H. Alexander^*

^*Corresponding author for this work

Wolfson SPaRC

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

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Abstract

In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes associated with these events and their characterization. We identify the inhibitor profile for these enzymes and the status of therapeutic exploitation, which to date has been limited to clinical trials for fatty acid amide hydrolase inhibitors. To bring the review to a close, we consider whether point block of a single enzyme is likely to be the most successful approach for therapeutic exploitation of the endocannabinoid system.

Original language	English
Journal	Advances in Pharmacology
Volume	80
DOIs	https://doi.org/10.1016/bs.apha.2017.03.006
Publication status	E-pub ahead of print - 25 May 2017

Keywords

2-Arachidonoylglycerol
Anandamide
Diacylglycerol lipase
Fatty acid amide hydrolase
Monoacylglycerol lipase
N-acylphosphatidylethanolamine phospholipase D

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10.1016/bs.apha.2017.03.006

Endocannabinoid turnover_FOWLER_Publishedonline25May2017_GREEN AAMAccepted author manuscript, 898 KBLicence: Other

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title = "Endocannabinoid Turnover",

abstract = "In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes associated with these events and their characterization. We identify the inhibitor profile for these enzymes and the status of therapeutic exploitation, which to date has been limited to clinical trials for fatty acid amide hydrolase inhibitors. To bring the review to a close, we consider whether point block of a single enzyme is likely to be the most successful approach for therapeutic exploitation of the endocannabinoid system.",

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T1 - Endocannabinoid Turnover

AU - Fowler, Christopher J.

AU - Doherty, Patrick

AU - Alexander, Stephen P.H.

PY - 2017/5/25

Y1 - 2017/5/25

N2 - In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes associated with these events and their characterization. We identify the inhibitor profile for these enzymes and the status of therapeutic exploitation, which to date has been limited to clinical trials for fatty acid amide hydrolase inhibitors. To bring the review to a close, we consider whether point block of a single enzyme is likely to be the most successful approach for therapeutic exploitation of the endocannabinoid system.

AB - In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes associated with these events and their characterization. We identify the inhibitor profile for these enzymes and the status of therapeutic exploitation, which to date has been limited to clinical trials for fatty acid amide hydrolase inhibitors. To bring the review to a close, we consider whether point block of a single enzyme is likely to be the most successful approach for therapeutic exploitation of the endocannabinoid system.

KW - 2-Arachidonoylglycerol

KW - Anandamide

KW - Diacylglycerol lipase

KW - Fatty acid amide hydrolase

KW - Monoacylglycerol lipase

KW - N-acylphosphatidylethanolamine phospholipase D

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U2 - 10.1016/bs.apha.2017.03.006

DO - 10.1016/bs.apha.2017.03.006

M3 - Article

AN - SCOPUS:85019834884

SN - 1054-3589

VL - 80

JO - Advances in Pharmacology

JF - Advances in Pharmacology

ER -

Endocannabinoid Turnover

Abstract

Keywords

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