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Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth

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Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth. / Kuhrt, Katy; Unwin, Christina; Hezelgrave, Natasha; Seed, Paul; Shennan, Andrew.

In: JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE, Vol. 27, No. 15, 01.10.2014, p. 1576-1579.

Research output: Contribution to journalArticle

Harvard

Kuhrt, K, Unwin, C, Hezelgrave, N, Seed, P & Shennan, A 2014, 'Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth', JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE, vol. 27, no. 15, pp. 1576-1579. https://doi.org/10.3109/14767058.2013.870550

APA

Kuhrt, K., Unwin, C., Hezelgrave, N., Seed, P., & Shennan, A. (2014). Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth. JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE, 27(15), 1576-1579. https://doi.org/10.3109/14767058.2013.870550

Vancouver

Kuhrt K, Unwin C, Hezelgrave N, Seed P, Shennan A. Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth. JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE. 2014 Oct 1;27(15):1576-1579. https://doi.org/10.3109/14767058.2013.870550

Author

Kuhrt, Katy ; Unwin, Christina ; Hezelgrave, Natasha ; Seed, Paul ; Shennan, Andrew. / Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth. In: JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE. 2014 ; Vol. 27, No. 15. pp. 1576-1579.

Bibtex Download

@article{36e4c697d8744b7587ce999f20a7a628,
title = "Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth",
abstract = "Objective: Accurate prediction of spontaneous preterm birth (sPTB) is essential to target interventions. Fetal fibronectin (fFN) is a leading predictor. A quantitative fFN (qfFN) test has improved prediction, based on high vaginal swabs (HVS). It is not known how endocervical (ECS) fFN levels compare, or which has the best predictive value. Our principal aim was to determine the difference in fFN concentration between HVS and ECS and compare their ability to predict sPTB.Methods: Asymptomatic high risk women (18+0–30+0 weeks gestation) had secretions sampled from the endocervix (ECS) and vaginal fornix (HVS), analyzed by the quantitative fFN analyzer (Hologic). Mean concentrations were compared; ROC curves were calculated using area under the curve (AUC) for prediction of delivery <30 and 37 weeks.Results: Mean HVS value was lower than ECS (80 ng/ml (SD142) versus 217 (SD 212) (p < 0.05). Predictive ability was similar: AUC of 0.92 and 0.94, respectively, for prediction of sPTB < 37 and 0.84 and 0.82 for <30 weeks.Conclusions: Endocervical qfFN is higher than HVS and clinicians should avoid ECS if using traditional thresholds. ECS and HVS are both useful predictors, but require different threshold values. Further work is needed to determine whether ECS is a better and safe test to justify the difficulty in sampling.",
keywords = "Predictive test, Premature labour, Sampling site",
author = "Katy Kuhrt and Christina Unwin and Natasha Hezelgrave and Paul Seed and Andrew Shennan",
year = "2014",
month = "10",
day = "1",
doi = "10.3109/14767058.2013.870550",
language = "English",
volume = "27",
pages = "1576--1579",
journal = "JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE",
issn = "1476-7058",
publisher = "Taylor & Francis",
number = "15",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth

AU - Kuhrt, Katy

AU - Unwin, Christina

AU - Hezelgrave, Natasha

AU - Seed, Paul

AU - Shennan, Andrew

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objective: Accurate prediction of spontaneous preterm birth (sPTB) is essential to target interventions. Fetal fibronectin (fFN) is a leading predictor. A quantitative fFN (qfFN) test has improved prediction, based on high vaginal swabs (HVS). It is not known how endocervical (ECS) fFN levels compare, or which has the best predictive value. Our principal aim was to determine the difference in fFN concentration between HVS and ECS and compare their ability to predict sPTB.Methods: Asymptomatic high risk women (18+0–30+0 weeks gestation) had secretions sampled from the endocervix (ECS) and vaginal fornix (HVS), analyzed by the quantitative fFN analyzer (Hologic). Mean concentrations were compared; ROC curves were calculated using area under the curve (AUC) for prediction of delivery <30 and 37 weeks.Results: Mean HVS value was lower than ECS (80 ng/ml (SD142) versus 217 (SD 212) (p < 0.05). Predictive ability was similar: AUC of 0.92 and 0.94, respectively, for prediction of sPTB < 37 and 0.84 and 0.82 for <30 weeks.Conclusions: Endocervical qfFN is higher than HVS and clinicians should avoid ECS if using traditional thresholds. ECS and HVS are both useful predictors, but require different threshold values. Further work is needed to determine whether ECS is a better and safe test to justify the difficulty in sampling.

AB - Objective: Accurate prediction of spontaneous preterm birth (sPTB) is essential to target interventions. Fetal fibronectin (fFN) is a leading predictor. A quantitative fFN (qfFN) test has improved prediction, based on high vaginal swabs (HVS). It is not known how endocervical (ECS) fFN levels compare, or which has the best predictive value. Our principal aim was to determine the difference in fFN concentration between HVS and ECS and compare their ability to predict sPTB.Methods: Asymptomatic high risk women (18+0–30+0 weeks gestation) had secretions sampled from the endocervix (ECS) and vaginal fornix (HVS), analyzed by the quantitative fFN analyzer (Hologic). Mean concentrations were compared; ROC curves were calculated using area under the curve (AUC) for prediction of delivery <30 and 37 weeks.Results: Mean HVS value was lower than ECS (80 ng/ml (SD142) versus 217 (SD 212) (p < 0.05). Predictive ability was similar: AUC of 0.92 and 0.94, respectively, for prediction of sPTB < 37 and 0.84 and 0.82 for <30 weeks.Conclusions: Endocervical qfFN is higher than HVS and clinicians should avoid ECS if using traditional thresholds. ECS and HVS are both useful predictors, but require different threshold values. Further work is needed to determine whether ECS is a better and safe test to justify the difficulty in sampling.

KW - Predictive test

KW - Premature labour

KW - Sampling site

UR - http://www.scopus.com/inward/record.url?scp=84907055558&partnerID=8YFLogxK

U2 - 10.3109/14767058.2013.870550

DO - 10.3109/14767058.2013.870550

M3 - Article

C2 - 24294948

VL - 27

SP - 1576

EP - 1579

JO - JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE

JF - JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE

SN - 1476-7058

IS - 15

ER -

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