Endocrine and genetic moderation of serotonin systems and the psychopathology of affective disorders

TY - CHAP

T1 - Endocrine and genetic moderation of serotonin systems and the psychopathology of affective disorders

AU - Tricklebank, Mark D.

AU - Daly, Eileen

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The selective serotonin reuptake inhibitors (SSRIs) have taught us much about the pathophysiology of depression particularly about the impact that polymorphisms in the transporter gene seemed to have on susceptibility to depression have that seemed to explain the association between early life trauma and subsequent development of depression. Neuroimaging studies lent strong support for this hypothesis: finding a strong amplification of the activation of the amygdala in response to anger or fear-provoking stimuli in healthy short (S) allele carriers compared to those carrying the long (L) allele. Preclinical studies using transgenic animals carrying the S or L alleles, exposed to an SSRI in early life, suggested that amygdaloid reactivity is developmentally determined. The story is yet more complicated as further studies have identified a further 10 polymorphisms in the serotonin transporter whose functional consequences and interaction with environmental events are currently unknown.

AB - The selective serotonin reuptake inhibitors (SSRIs) have taught us much about the pathophysiology of depression particularly about the impact that polymorphisms in the transporter gene seemed to have on susceptibility to depression have that seemed to explain the association between early life trauma and subsequent development of depression. Neuroimaging studies lent strong support for this hypothesis: finding a strong amplification of the activation of the amygdala in response to anger or fear-provoking stimuli in healthy short (S) allele carriers compared to those carrying the long (L) allele. Preclinical studies using transgenic animals carrying the S or L alleles, exposed to an SSRI in early life, suggested that amygdaloid reactivity is developmentally determined. The story is yet more complicated as further studies have identified a further 10 polymorphisms in the serotonin transporter whose functional consequences and interaction with environmental events are currently unknown.

KW - Polymorphisms adrenal-pituitary axis

KW - Selective serotonin reuptake inhibitor

KW - Serotonin transporter gene

UR - http://www.scopus.com/inward/record.url?scp=85081932373&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-813323-1.00006-2

DO - 10.1016/B978-0-12-813323-1.00006-2

M3 - Chapter

SN - 9780128133248

SP - 105

EP - 115

BT - The Serotonin System

PB - Elsevier

ER -