Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart

Georgina M Ellison, Daniele Torella, Santo Dellegrottaglie, Claudia Perez-Martinez, Armando Perez de Prado, Carla Vicinanza, Saranya Purushothaman, Valentina Galuppo, Claudio Iaconetti, Cheryl D Waring, Andrew Smith, Michele Torella, Carlos Cuellas Ramon, Jose Manuel Gonzalo-Orden, Valter Agosti, Ciro Indolfi, Manuel Galiñanes, Felipe Fernandez-Vazquez, Bernardo Nadal-Ginard

Research output: Contribution to journalArticlepeer-review

204 Citations (Scopus)

Abstract

The purpose of this study was to test the ability of insulin-like growth factor (IGF)-1/hepatocyte growth factor (HGF) to activate resident endogenous porcine cardiac stem/progenitor cells (epCSCs) and to promote myocardial repair through a clinically applicable intracoronary injection protocol in a pig model of myocardial infarction (MI) relevant to human disease.
Original languageEnglish
Pages (from-to)977-86
Number of pages10
JournalJournal of the American College of Cardiology
Volume58
Issue number9
DOIs
Publication statusPublished - 23 Aug 2011

Keywords

  • Swine
  • Animals
  • Coronary Vessels
  • Injections, Intra-Arterial
  • Humans
  • Cell Differentiation
  • Insulin-Like Growth Factor I
  • Cell Survival
  • Drug Therapy, Combination
  • Stem Cells
  • Hepatocyte Growth Factor
  • Myocardial Infarction
  • Myocytes, Cardiac
  • Female

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