Endoplasmic reticulum stress in arterial smooth muscle cells: A novel regulator of vascular disease

Catherine M. Shanahan; Malgorzata Furmanik

doi:10.2174/1573403X12666161014094738

Endoplasmic reticulum stress in arterial smooth muscle cells: A novel regulator of vascular disease

Catherine M. Shanahan^*, Malgorzata Furmanik

^*Corresponding author for this work

Cardiovascular Sciences

Maastricht University

Research output: Contribution to journal › Review article › peer-review

40 Citations (Scopus)

Abstract

Cardiovascular disease continues to be the leading cause of death in industrialised societies. The idea that the arterial smooth muscle cell (ASMC) plays a key role in regulating many vascular pathologies has been gaining importance, as has the realisation that not enough is known about the pathological cellular mechanisms regulating ASMC function in vascular remodelling. In the past decade endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been recognised as a stress response underlying many physiological and pathological processes in various vascular cell types. Here we summarise what is known about how ER stress signalling regulates phenotypic switching, trans/dedifferentiation and apoptosis of ASMCs and contributes to atherosclerosis, hypertension, aneurysms and vascular calcification.

Original language	English
Pages (from-to)	94-105
Number of pages	12
Journal	Current Cardiology Reviews
Volume	13
Issue number	2
DOIs	https://doi.org/10.2174/1573403X12666161014094738
Publication status	Published - 2017

Keywords

Atherosclerosis
ER stress
Vascular calcification
Vascular smooth muscle cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/1573403X12666161014094738

Cite this

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abstract = "Cardiovascular disease continues to be the leading cause of death in industrialised societies. The idea that the arterial smooth muscle cell (ASMC) plays a key role in regulating many vascular pathologies has been gaining importance, as has the realisation that not enough is known about the pathological cellular mechanisms regulating ASMC function in vascular remodelling. In the past decade endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been recognised as a stress response underlying many physiological and pathological processes in various vascular cell types. Here we summarise what is known about how ER stress signalling regulates phenotypic switching, trans/dedifferentiation and apoptosis of ASMCs and contributes to atherosclerosis, hypertension, aneurysms and vascular calcification.",

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AB - Cardiovascular disease continues to be the leading cause of death in industrialised societies. The idea that the arterial smooth muscle cell (ASMC) plays a key role in regulating many vascular pathologies has been gaining importance, as has the realisation that not enough is known about the pathological cellular mechanisms regulating ASMC function in vascular remodelling. In the past decade endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been recognised as a stress response underlying many physiological and pathological processes in various vascular cell types. Here we summarise what is known about how ER stress signalling regulates phenotypic switching, trans/dedifferentiation and apoptosis of ASMCs and contributes to atherosclerosis, hypertension, aneurysms and vascular calcification.

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Endoplasmic reticulum stress in arterial smooth muscle cells: A novel regulator of vascular disease

Abstract

Keywords

UN SDGs

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