Endoplasmic Reticulum stress in chronic kidney disease. New molecular targets from bench to the bedside

Carlo Alberto Ricciardi; Luigi Gnudi

Endoplasmic Reticulum stress in chronic kidney disease. New molecular targets from bench to the bedside

Carlo Alberto Ricciardi, Luigi Gnudi

Vascular Biology & Inflammation

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

The identification of new biomarkers/pharmacological targets for chronic kidney disease (CKD) is required for the development of more effective therapies. Several studies in vitro and in vivo have shown the importance of the endoplasmic reticulum (ER) (cellular organelle devolved to protein biosynthesis and maturation, and cellular detoxification processes) in the pathophysiology of CKD. Hence, the synthesis and development of novel drugs against the different ER intracellular pathways is crucial in order to slow down the development and progression of renal diseases. This review aims to dissect the role of the different ER branches (PERK, IRE1α, ATF6) and their function in CKD, providing potential insights for the development of new treatments.

Original language	English
Journal	Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia
Volume	36
Issue number	6
Publication status	Published - 9 Dec 2019

Keywords

chronic kidney disease
endoplasmic reticulum
reticulon
unfolded protein response

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The identification of new biomarkers/pharmacological targets for chronic kidney disease (CKD) is required for the development of more effective therapies. Several studies in vitro and in vivo have shown the importance of the endoplasmic reticulum (ER) (cellular organelle devolved to protein biosynthesis and maturation, and cellular detoxification processes) in the pathophysiology of CKD. Hence, the synthesis and development of novel drugs against the different ER intracellular pathways is crucial in order to slow down the development and progression of renal diseases. This review aims to dissect the role of the different ER branches (PERK, IRE1α, ATF6) and their function in CKD, providing potential insights for the development of new treatments.",

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T1 - Endoplasmic Reticulum stress in chronic kidney disease. New molecular targets from bench to the bedside

AU - Ricciardi, Carlo Alberto

AU - Gnudi, Luigi

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N2 - The identification of new biomarkers/pharmacological targets for chronic kidney disease (CKD) is required for the development of more effective therapies. Several studies in vitro and in vivo have shown the importance of the endoplasmic reticulum (ER) (cellular organelle devolved to protein biosynthesis and maturation, and cellular detoxification processes) in the pathophysiology of CKD. Hence, the synthesis and development of novel drugs against the different ER intracellular pathways is crucial in order to slow down the development and progression of renal diseases. This review aims to dissect the role of the different ER branches (PERK, IRE1α, ATF6) and their function in CKD, providing potential insights for the development of new treatments.

AB - The identification of new biomarkers/pharmacological targets for chronic kidney disease (CKD) is required for the development of more effective therapies. Several studies in vitro and in vivo have shown the importance of the endoplasmic reticulum (ER) (cellular organelle devolved to protein biosynthesis and maturation, and cellular detoxification processes) in the pathophysiology of CKD. Hence, the synthesis and development of novel drugs against the different ER intracellular pathways is crucial in order to slow down the development and progression of renal diseases. This review aims to dissect the role of the different ER branches (PERK, IRE1α, ATF6) and their function in CKD, providing potential insights for the development of new treatments.

KW - chronic kidney disease

KW - endoplasmic reticulum

KW - reticulon

KW - unfolded protein response

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SN - 1724-5990

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JO - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

JF - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

IS - 6

ER -

Endoplasmic Reticulum stress in chronic kidney disease. New molecular targets from bench to the bedside

Abstract

Keywords

UN SDGs

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