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Endothelial and platelet microparticles in patients with antiphospholipid antibodies

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Endothelial and platelet microparticles in patients with antiphospholipid antibodies. / Breen, K. A.; Sanchez, K.; Kirkman, N.; Seed, P. T.; Parmar, K.; Moore, G. W.; Hunt, B. J.

In: Thrombosis Research, Vol. 135, No. 2, 01.02.2015, p. 368-374.

Research output: Contribution to journalArticle

Harvard

Breen, KA, Sanchez, K, Kirkman, N, Seed, PT, Parmar, K, Moore, GW & Hunt, BJ 2015, 'Endothelial and platelet microparticles in patients with antiphospholipid antibodies', Thrombosis Research, vol. 135, no. 2, pp. 368-374. https://doi.org/10.1016/j.thromres.2014.11.027

APA

Breen, K. A., Sanchez, K., Kirkman, N., Seed, P. T., Parmar, K., Moore, G. W., & Hunt, B. J. (2015). Endothelial and platelet microparticles in patients with antiphospholipid antibodies. Thrombosis Research, 135(2), 368-374. https://doi.org/10.1016/j.thromres.2014.11.027

Vancouver

Breen KA, Sanchez K, Kirkman N, Seed PT, Parmar K, Moore GW et al. Endothelial and platelet microparticles in patients with antiphospholipid antibodies. Thrombosis Research. 2015 Feb 1;135(2):368-374. https://doi.org/10.1016/j.thromres.2014.11.027

Author

Breen, K. A. ; Sanchez, K. ; Kirkman, N. ; Seed, P. T. ; Parmar, K. ; Moore, G. W. ; Hunt, B. J. / Endothelial and platelet microparticles in patients with antiphospholipid antibodies. In: Thrombosis Research. 2015 ; Vol. 135, No. 2. pp. 368-374.

Bibtex Download

@article{ba6ea02825e747e8b002d192fa93af66,
title = "Endothelial and platelet microparticles in patients with antiphospholipid antibodies",
abstract = "Background: The antiphospholipid syndrome (APS) is the association of thrombosis and recurrent pregnancy loss and/or pregnancy morbidity with persistent antiphospholipid antibodies (aPL). Previous studies of microparticles in patients with APS/aPL have mainly been small and findings, contradictory. Objectives: To quantify endothelial and platelet microparticle levels in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome (PAPS). Patients/Methods: We measured endothelial and platelet microparticle levels by flow cytometry in 66 aPL/PAPS patients and 18 healthy controls. Results: Levels of circulating platelet (CD41 and CD61) and endothelial microparticles (CD51 and CD105) were significantly increased in patients with PAPS and aPL compared to healthy controls. There were correlations between platelet and endothelial microparticles levels in all patients with aPL. Conclusions: Platelet and endothelial microparticles are increased in all patient groups within this cohort of patients aPL. Whether they may have a role in the pathogenesis of APS merits further study.",
keywords = "Antiphospholipid antibodies, Antiphospholipid syndrome, Microparticles",
author = "Breen, {K. A.} and K. Sanchez and N. Kirkman and Seed, {P. T.} and K. Parmar and Moore, {G. W.} and Hunt, {B. J.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1016/j.thromres.2014.11.027",
language = "English",
volume = "135",
pages = "368--374",
journal = "Thrombosis Research",
issn = "0049-3848",
publisher = "Elsevier Limited",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Endothelial and platelet microparticles in patients with antiphospholipid antibodies

AU - Breen, K. A.

AU - Sanchez, K.

AU - Kirkman, N.

AU - Seed, P. T.

AU - Parmar, K.

AU - Moore, G. W.

AU - Hunt, B. J.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Background: The antiphospholipid syndrome (APS) is the association of thrombosis and recurrent pregnancy loss and/or pregnancy morbidity with persistent antiphospholipid antibodies (aPL). Previous studies of microparticles in patients with APS/aPL have mainly been small and findings, contradictory. Objectives: To quantify endothelial and platelet microparticle levels in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome (PAPS). Patients/Methods: We measured endothelial and platelet microparticle levels by flow cytometry in 66 aPL/PAPS patients and 18 healthy controls. Results: Levels of circulating platelet (CD41 and CD61) and endothelial microparticles (CD51 and CD105) were significantly increased in patients with PAPS and aPL compared to healthy controls. There were correlations between platelet and endothelial microparticles levels in all patients with aPL. Conclusions: Platelet and endothelial microparticles are increased in all patient groups within this cohort of patients aPL. Whether they may have a role in the pathogenesis of APS merits further study.

AB - Background: The antiphospholipid syndrome (APS) is the association of thrombosis and recurrent pregnancy loss and/or pregnancy morbidity with persistent antiphospholipid antibodies (aPL). Previous studies of microparticles in patients with APS/aPL have mainly been small and findings, contradictory. Objectives: To quantify endothelial and platelet microparticle levels in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome (PAPS). Patients/Methods: We measured endothelial and platelet microparticle levels by flow cytometry in 66 aPL/PAPS patients and 18 healthy controls. Results: Levels of circulating platelet (CD41 and CD61) and endothelial microparticles (CD51 and CD105) were significantly increased in patients with PAPS and aPL compared to healthy controls. There were correlations between platelet and endothelial microparticles levels in all patients with aPL. Conclusions: Platelet and endothelial microparticles are increased in all patient groups within this cohort of patients aPL. Whether they may have a role in the pathogenesis of APS merits further study.

KW - Antiphospholipid antibodies

KW - Antiphospholipid syndrome

KW - Microparticles

UR - http://www.scopus.com/inward/record.url?scp=84921604714&partnerID=8YFLogxK

U2 - 10.1016/j.thromres.2014.11.027

DO - 10.1016/j.thromres.2014.11.027

M3 - Article

AN - SCOPUS:84921604714

VL - 135

SP - 368

EP - 374

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 2

ER -

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